Description: Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 2, mRNA. RefSeq Summary (NM_005348): The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]. Transcript (Including UTRs) Position: hg19 chr14:102,549,002-102,552,715 Size: 3,714 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr14:102,549,347-102,551,760 Size: 2,414 Coding Exon Count: 6
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 54211 - Ribosomal protein S5 domain 2-like
ModBase Predicted Comparative 3D Structure on Q86U12
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
GQ149083 - Homo sapiens epididymis luminal secretory protein 52 (EL52) mRNA, complete cds. AJ890083 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 4 (HSPCA gene). BC007989 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3030617), partial cds. BC000987 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3446372), partial cds. BC023006 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:4404328), partial cds. BC017233 - Homo sapiens cDNA clone IMAGE:4299683, containing frame-shift errors. AK129557 - Homo sapiens cDNA FLJ26046 fis, clone PRS02194, highly similar to Heat shock protein HSP 90-alpha (HSP 86). AJ890082 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 2 (HSPCA gene). AK056446 - Homo sapiens cDNA FLJ31884 fis, clone NT2RP7002906, highly similar to Homo sapiens heat shock 90 kDa protein 1, alpha (HSPCA), transcript variant 1, mRNA. D87666 - Homo sapiens heart mRNA for heat shock protein 90, partial cds. AF028832 - Homo sapiens Hsp89-alpha-delta-N mRNA, complete cds. X15183 - Human mRNA for 90-kDa heat-shock protein. BC121062 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone MGC:149801 IMAGE:40118488), complete cds. GQ472230 - Homo sapiens epididymis secretory sperm binding protein Li 65p (HEL-S-65p) mRNA, complete cds. AK291607 - Homo sapiens cDNA FLJ75475 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA. AK300126 - Homo sapiens cDNA FLJ57431 complete cds, highly similar to Heat shock protein HSP 90-alpha. AK291115 - Homo sapiens cDNA FLJ78691 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA. KJ905786 - Synthetic construct Homo sapiens clone ccsbBroadEn_15456 HSP90AA1 gene, encodes complete protein. KJ897018 - Synthetic construct Homo sapiens clone ccsbBroadEn_06412 HSP90AA1 gene, encodes complete protein. KJ897019 - Synthetic construct Homo sapiens clone ccsbBroadEn_06413 HSP90AA1 gene, encodes complete protein. AB590828 - Synthetic construct DNA, clone: pFN21AB8480, Homo sapiens HSP90AA1 gene for heat shock protein 90kDa alpha (cytosolic), class A member 1, without stop codon, in Flexi system. BX247955 - human full-length cDNA clone CS0CAP007YF18 of Thymus of Homo sapiens (human). JD063161 - Sequence 44185 from Patent EP1572962. JD204593 - Sequence 185617 from Patent EP1572962. JD142887 - Sequence 123911 from Patent EP1572962. JD065927 - Sequence 46951 from Patent EP1572962. JD472388 - Sequence 453412 from Patent EP1572962. JD472389 - Sequence 453413 from Patent EP1572962. BC108695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:6527590), partial cds. DQ580653 - Homo sapiens piRNA piR-48765, complete sequence. AK310595 - Homo sapiens cDNA, FLJ17637. X07270 - Human mRNA for heat shock protein hsp86. BC001695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3050343). BX248761 - human full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens (human).
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04612 - Antigen processing and presentation hsa04621 - NOD-like receptor signaling pathway hsa04914 - Progesterone-mediated oocyte maturation hsa05200 - Pathways in cancer hsa05215 - Prostate cancer
BioCarta from NCI Cancer Genome Anatomy Project h_no1Pathway - Actions of Nitric Oxide in the Heart h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system h_aktPathway - AKT Signaling Pathway h_gcrPathway - Corticosteroids and cardioprotection h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality h_acrPathway - Ahr Signal Transduction Pathway h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)