Human Gene HSP90AA1 (uc001ykw.1)
  Description: Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1 (HSP90AA1), transcript variant 2, mRNA.
RefSeq Summary (NM_005348): The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Transcript (Including UTRs)
   Position: hg19 chr14:102,549,002-102,552,715 Size: 3,714 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr14:102,549,347-102,551,760 Size: 2,414 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:102,549,002-102,552,715)mRNA (may differ from genome)Protein (413 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIPubMed
UniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): HSP90AA1
CDC HuGE Published Literature: HSP90AA1

-  MalaCards Disease Associations
  MalaCards Gene Search: HSP90AA1
Diseases sorted by gene-association score: epidermolysis bullosa acquisita (10), hypersensitivity vasculitis (10), hypersensitivity reaction type iii disease (9), candidiasis (9), lobular neoplasia (9), neuronal intranuclear inclusion disease (7), henoch-schoenlein purpura (6), monoclonal paraproteinemia (6), senile angioma (5), small cell sarcoma (5), spinal and bulbar muscular atrophy of kennedy (5), chronic mucocutaneous candidiasis (4), prostate cancer (4), enchondromatosis, multiple, ollier type (4), juxtacortical osteosarcoma (4), peripheral osteosarcoma (3), gastrointestinal stromal tumor (3), lung cancer (2), colorectal cancer (2), leukemia, chronic myeloid, somatic (2), malaria (1), leber congenital amaurosis (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 449.02 RPKM in Testis
Total median expression: 10701.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.40170-0.226 Picture PostScript Text
3' UTR -129.00345-0.374 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003594 - ATPase-like_ATP-bd
IPR001404 - Hsp90
IPR020575 - Hsp90_N
IPR020568 - Ribosomal_S5_D2-typ_fold

Pfam Domains:
PF00183 - Hsp90 protein

SCOP Domains:
55874 - ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
54211 - Ribosomal protein S5 domain 2-like

ModBase Predicted Comparative 3D Structure on Q86U12
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005524 ATP binding
GO:0051082 unfolded protein binding

Biological Process:
GO:0006457 protein folding
GO:0006950 response to stress


-  Descriptions from all associated GenBank mRNAs
  GQ149083 - Homo sapiens epididymis luminal secretory protein 52 (EL52) mRNA, complete cds.
AJ890083 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 4 (HSPCA gene).
BC007989 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3030617), partial cds.
BC000987 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3446372), partial cds.
BC023006 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:4404328), partial cds.
BC017233 - Homo sapiens cDNA clone IMAGE:4299683, containing frame-shift errors.
AK129557 - Homo sapiens cDNA FLJ26046 fis, clone PRS02194, highly similar to Heat shock protein HSP 90-alpha (HSP 86).
AJ890082 - Homo sapiens mRNA for Heat shock protein HSP 90-alpha 2 (HSPCA gene).
AK056446 - Homo sapiens cDNA FLJ31884 fis, clone NT2RP7002906, highly similar to Homo sapiens heat shock 90 kDa protein 1, alpha (HSPCA), transcript variant 1, mRNA.
D87666 - Homo sapiens heart mRNA for heat shock protein 90, partial cds.
AF028832 - Homo sapiens Hsp89-alpha-delta-N mRNA, complete cds.
X15183 - Human mRNA for 90-kDa heat-shock protein.
BC121062 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone MGC:149801 IMAGE:40118488), complete cds.
GQ472230 - Homo sapiens epididymis secretory sperm binding protein Li 65p (HEL-S-65p) mRNA, complete cds.
AK291607 - Homo sapiens cDNA FLJ75475 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA.
AK300126 - Homo sapiens cDNA FLJ57431 complete cds, highly similar to Heat shock protein HSP 90-alpha.
AK291115 - Homo sapiens cDNA FLJ78691 complete cds, highly similar to Homo sapiens heat shock 90kDa protein 1, alpha (HSPCA), transcript variant 2, mRNA.
KJ905786 - Synthetic construct Homo sapiens clone ccsbBroadEn_15456 HSP90AA1 gene, encodes complete protein.
KJ897018 - Synthetic construct Homo sapiens clone ccsbBroadEn_06412 HSP90AA1 gene, encodes complete protein.
KJ897019 - Synthetic construct Homo sapiens clone ccsbBroadEn_06413 HSP90AA1 gene, encodes complete protein.
AB590828 - Synthetic construct DNA, clone: pFN21AB8480, Homo sapiens HSP90AA1 gene for heat shock protein 90kDa alpha (cytosolic), class A member 1, without stop codon, in Flexi system.
BX247955 - human full-length cDNA clone CS0CAP007YF18 of Thymus of Homo sapiens (human).
JD063161 - Sequence 44185 from Patent EP1572962.
JD204593 - Sequence 185617 from Patent EP1572962.
JD142887 - Sequence 123911 from Patent EP1572962.
JD065927 - Sequence 46951 from Patent EP1572962.
JD472388 - Sequence 453412 from Patent EP1572962.
JD472389 - Sequence 453413 from Patent EP1572962.
BC108695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:6527590), partial cds.
DQ580653 - Homo sapiens piRNA piR-48765, complete sequence.
AK310595 - Homo sapiens cDNA, FLJ17637.
X07270 - Human mRNA for heat shock protein hsp86.
BC001695 - Homo sapiens heat shock protein 90kDa alpha (cytosolic), class A member 1, mRNA (cDNA clone IMAGE:3050343).
BX248761 - human full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens (human).

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa04612 - Antigen processing and presentation
hsa04621 - NOD-like receptor signaling pathway
hsa04914 - Progesterone-mediated oocyte maturation
hsa05200 - Pathways in cancer
hsa05215 - Prostate cancer

BioCarta from NCI Cancer Genome Anatomy Project
h_no1Pathway - Actions of Nitric Oxide in the Heart
h_p53hypoxiaPathway - Hypoxia and p53 in the Cardiovascular system
h_aktPathway - AKT Signaling Pathway
h_gcrPathway - Corticosteroids and cardioprotection
h_telPathway - Telomeres, Telomerase, Cellular Aging, and Immortality
h_acrPathway - Ahr Signal Transduction Pathway
h_hifPathway - Hypoxia-Inducible Factor in the Cardiovascular System
h_pparaPathway - Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)

-  Other Names for This Gene
  Alternate Gene Symbols: BX247955, Q86U12, Q86U12_HUMAN
UCSC ID: uc001ykw.1
RefSeq Accession: NM_005348
Protein: Q86U12

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BX247955.1
exon count: 7CDS single in 3' UTR: no RNA size: 1710
ORF size: 1242CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2317.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 369# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.