Human Gene KLC1 (uc001yns.3)
  Description: Homo sapiens kinesin light chain 1 (KLC1), transcript variant 2, mRNA.
RefSeq Summary (NM_182923): Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008].
Transcript (Including UTRs)
   Position: hg19 chr14:104,142,026-104,167,888 Size: 25,863 Total Exon Count: 5 Strand: +


Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionOther SpeciesmRNA DescriptionsOther NamesModel Information
Methods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr14:104,142,026-104,167,888)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
BioGPSEnsemblExonPrimerGeneNetworkH-INVHGNC
LynxMalacardsPubMedTreefamWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): KLC1
CDC HuGE Published Literature: KLC1

-  MalaCards Disease Associations
  MalaCards Gene Search: KLC1
Diseases sorted by gene-association score: medulloblastoma (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 33.00 RPKM in Nerve - Tibial
Total median expression: 967.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK299527 - Homo sapiens cDNA FLJ55519 complete cds, highly similar to Kinesin light chain 1.
AK294508 - Homo sapiens cDNA FLJ61233 complete cds, highly similar to Kinesin light chain 1.
BC008881 - Homo sapiens kinesin light chain 1, mRNA (cDNA clone MGC:15245 IMAGE:4301579), complete cds.
L04733 - Homo sapiens kinesin light chain mRNA, complete cds.
AY180164 - Homo sapiens kinesin light chain 1C (KNS2) mRNA, complete cds.
DQ893256 - Synthetic construct clone IMAGE:100005886; FLH195673.01X; RZPDo839F01152D kinesin 2 (KNS2) gene, encodes complete protein.
DQ896585 - Synthetic construct Homo sapiens clone IMAGE:100011045; FLH195669.01L; RZPDo839F01151D kinesin 2 (KNS2) gene, encodes complete protein.
KJ891518 - Synthetic construct Homo sapiens clone ccsbBroadEn_00912 KLC1 gene, encodes complete protein.
AB385087 - Synthetic construct DNA, clone: pF1KB5346, Homo sapiens KLC1 gene for kinesin light chain 1, complete cds, without stop codon, in Flexi system.
AB451431 - Homo sapiens KLC1 mRNA for kinesin light chain 1, partial cds, clone: FLJ08153AAAF.
AB451299 - Homo sapiens KLC1 mRNA for kinesin light chain 1, complete cds, clone: FLJ08153AAAN.
AY180163 - Homo sapiens kinesin light chain 1S (KNS2) mRNA, partial cds.
AY244715 - Homo sapiens kinesin light chain 1B (KNS2) mRNA, partial cds; alternatively spliced.
AY180166 - Homo sapiens kinesin light chain 1N (KNS2) mRNA, partial cds.
AY180170 - Homo sapiens kinesin light chain 1J (KNS2) mRNA, partial cds.
AY180167 - Homo sapiens kinesin light chain 1P (KNS2) mRNA, partial cds.
AY180169 - Homo sapiens kinesin light chain 1R (KNS2) mRNA, partial cds.
AY180168 - Homo sapiens kinesin light chain 1G (KNS2) mRNA, partial cds.
AY180165 - Homo sapiens kinesin light chain 1K (KNS2) mRNA, partial cds.
AL133587 - Homo sapiens mRNA; cDNA DKFZp434I139 (from clone DKFZp434I139).
JD125523 - Sequence 106547 from Patent EP1572962.
JD470036 - Sequence 451060 from Patent EP1572962.
JD228725 - Sequence 209749 from Patent EP1572962.
JD532740 - Sequence 513764 from Patent EP1572962.
JD090605 - Sequence 71629 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AY180168
UCSC ID: uc001yns.3
RefSeq Accession: NM_182923

-  Gene Model Information
 
category: nearCoding nonsense-mediated-decay: no RNA accession: AY180168.1
exon count: 5CDS single in 3' UTR: no RNA size: 689
ORF size: 0CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 572.00frame shift in genome: no % Coverage: 98.69
has start codon: no stop codon in genome: no # of Alignments: 1
has end codon: no retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.