Description: Homo sapiens kinesin light chain 1 (KLC1), transcript variant 2, mRNA. RefSeq Summary (NM_182923): Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr14:104,142,026-104,167,888 Size: 25,863 Total Exon Count: 5 Strand: +
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK299527 - Homo sapiens cDNA FLJ55519 complete cds, highly similar to Kinesin light chain 1. AK294508 - Homo sapiens cDNA FLJ61233 complete cds, highly similar to Kinesin light chain 1. BC008881 - Homo sapiens kinesin light chain 1, mRNA (cDNA clone MGC:15245 IMAGE:4301579), complete cds. L04733 - Homo sapiens kinesin light chain mRNA, complete cds. AY180164 - Homo sapiens kinesin light chain 1C (KNS2) mRNA, complete cds. DQ893256 - Synthetic construct clone IMAGE:100005886; FLH195673.01X; RZPDo839F01152D kinesin 2 (KNS2) gene, encodes complete protein. DQ896585 - Synthetic construct Homo sapiens clone IMAGE:100011045; FLH195669.01L; RZPDo839F01151D kinesin 2 (KNS2) gene, encodes complete protein. KJ891518 - Synthetic construct Homo sapiens clone ccsbBroadEn_00912 KLC1 gene, encodes complete protein. AB385087 - Synthetic construct DNA, clone: pF1KB5346, Homo sapiens KLC1 gene for kinesin light chain 1, complete cds, without stop codon, in Flexi system. AB451431 - Homo sapiens KLC1 mRNA for kinesin light chain 1, partial cds, clone: FLJ08153AAAF. AB451299 - Homo sapiens KLC1 mRNA for kinesin light chain 1, complete cds, clone: FLJ08153AAAN. AY180163 - Homo sapiens kinesin light chain 1S (KNS2) mRNA, partial cds. AY244715 - Homo sapiens kinesin light chain 1B (KNS2) mRNA, partial cds; alternatively spliced. AY180166 - Homo sapiens kinesin light chain 1N (KNS2) mRNA, partial cds. AY180170 - Homo sapiens kinesin light chain 1J (KNS2) mRNA, partial cds. AY180167 - Homo sapiens kinesin light chain 1P (KNS2) mRNA, partial cds. AY180169 - Homo sapiens kinesin light chain 1R (KNS2) mRNA, partial cds. AY180168 - Homo sapiens kinesin light chain 1G (KNS2) mRNA, partial cds. AY180165 - Homo sapiens kinesin light chain 1K (KNS2) mRNA, partial cds. AL133587 - Homo sapiens mRNA; cDNA DKFZp434I139 (from clone DKFZp434I139). JD125523 - Sequence 106547 from Patent EP1572962. JD470036 - Sequence 451060 from Patent EP1572962. JD228725 - Sequence 209749 from Patent EP1572962. JD532740 - Sequence 513764 from Patent EP1572962. JD090605 - Sequence 71629 from Patent EP1572962.