Human Gene ZNF770 (uc001ziw.3)
  Description: Homo sapiens zinc finger protein 770 (ZNF770), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr15:35,270,542-35,280,497 Size: 9,956 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr15:35,273,560-35,275,635 Size: 2,076 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:35,270,542-35,280,497)mRNA (may differ from genome)Protein (691 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkHGNCHPRDLynxMGIneXtProt
PubMedReactomeTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN770_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 770;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 11 C2H2-type zinc fingers.
SEQUENCE CAUTION: Sequence=BAD18579.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 12.20 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 136.48 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.70354-0.358 Picture PostScript Text
3' UTR -776.433018-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q6IQ21
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC071603 - Homo sapiens zinc finger protein 770, mRNA (cDNA clone MGC:87579 IMAGE:30340520), complete cds.
BC005188 - Homo sapiens hypothetical protein FLJ20582, mRNA (cDNA clone IMAGE:3510816), partial cds.
LF205831 - JP 2014500723-A/13334: Polycomb-Associated Non-Coding RNAs.
BC035308 - Homo sapiens cDNA clone IMAGE:4751395.
JD026622 - Sequence 7646 from Patent EP1572962.
JD027391 - Sequence 8415 from Patent EP1572962.
JD036100 - Sequence 17124 from Patent EP1572962.
JD029333 - Sequence 10357 from Patent EP1572962.
AK131433 - Homo sapiens cDNA FLJ16559 fis, clone SYNOV4002744.
AK127201 - Homo sapiens cDNA FLJ45266 fis, clone BRHIP2027077, weakly similar to Mus musculus Flt3 interacting zinc finger protein 1 (Fiz1).
LF348654 - JP 2014500723-A/156157: Polycomb-Associated Non-Coding RNAs.
LF348655 - JP 2014500723-A/156158: Polycomb-Associated Non-Coding RNAs.
JD074145 - Sequence 55169 from Patent EP1572962.
LF348656 - JP 2014500723-A/156159: Polycomb-Associated Non-Coding RNAs.
AK291438 - Homo sapiens cDNA FLJ77553 complete cds.
LF348657 - JP 2014500723-A/156160: Polycomb-Associated Non-Coding RNAs.
KJ899049 - Synthetic construct Homo sapiens clone ccsbBroadEn_08443 ZNF770 gene, encodes complete protein.
AB464771 - Synthetic construct DNA, clone: pF1KB9612, Homo sapiens ZNF770 gene for zinc finger protein 770, without stop codon, in Flexi system.
LF348658 - JP 2014500723-A/156161: Polycomb-Associated Non-Coding RNAs.
JD063772 - Sequence 44796 from Patent EP1572962.
JD283488 - Sequence 264512 from Patent EP1572962.
JD507015 - Sequence 488039 from Patent EP1572962.
CU687114 - Synthetic construct Homo sapiens gateway clone IMAGE:100023018 5' read ZNF770 mRNA.
JD289833 - Sequence 270857 from Patent EP1572962.
LF348659 - JP 2014500723-A/156162: Polycomb-Associated Non-Coding RNAs.
AK000589 - Homo sapiens cDNA FLJ20582 fis, clone KAT12156.
JD361142 - Sequence 342166 from Patent EP1572962.
LF348660 - JP 2014500723-A/156163: Polycomb-Associated Non-Coding RNAs.
LF348661 - JP 2014500723-A/156164: Polycomb-Associated Non-Coding RNAs.
JD075291 - Sequence 56315 from Patent EP1572962.
JD559478 - Sequence 540502 from Patent EP1572962.
LF348662 - JP 2014500723-A/156165: Polycomb-Associated Non-Coding RNAs.
JD360329 - Sequence 341353 from Patent EP1572962.
JD167216 - Sequence 148240 from Patent EP1572962.
JD235964 - Sequence 216988 from Patent EP1572962.
JD244305 - Sequence 225329 from Patent EP1572962.
JD350297 - Sequence 331321 from Patent EP1572962.
JD347628 - Sequence 328652 from Patent EP1572962.
LF348663 - JP 2014500723-A/156166: Polycomb-Associated Non-Coding RNAs.
JD402999 - Sequence 384023 from Patent EP1572962.
JD342677 - Sequence 323701 from Patent EP1572962.
JD346138 - Sequence 327162 from Patent EP1572962.
JD488544 - Sequence 469568 from Patent EP1572962.
JD077892 - Sequence 58916 from Patent EP1572962.
JD425713 - Sequence 406737 from Patent EP1572962.
MA584231 - JP 2018138019-A/156157: Polycomb-Associated Non-Coding RNAs.
MA584232 - JP 2018138019-A/156158: Polycomb-Associated Non-Coding RNAs.
MA584233 - JP 2018138019-A/156159: Polycomb-Associated Non-Coding RNAs.
MA584234 - JP 2018138019-A/156160: Polycomb-Associated Non-Coding RNAs.
MA584235 - JP 2018138019-A/156161: Polycomb-Associated Non-Coding RNAs.
MA584236 - JP 2018138019-A/156162: Polycomb-Associated Non-Coding RNAs.
MA584237 - JP 2018138019-A/156163: Polycomb-Associated Non-Coding RNAs.
MA584238 - JP 2018138019-A/156164: Polycomb-Associated Non-Coding RNAs.
MA584239 - JP 2018138019-A/156165: Polycomb-Associated Non-Coding RNAs.
MA584240 - JP 2018138019-A/156166: Polycomb-Associated Non-Coding RNAs.
MA441408 - JP 2018138019-A/13334: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6IQ21 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_014106, NP_054825, Q6IQ21, Q6ZMZ6, Q9NWV2, ZN770_HUMAN
UCSC ID: uc001ziw.3
RefSeq Accession: NM_014106
Protein: Q6IQ21 (aka ZN770_HUMAN)
CCDS: CCDS10042.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_014106.3
exon count: 3CDS single in 3' UTR: no RNA size: 5453
ORF size: 2076CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4220.00frame shift in genome: no % Coverage: 99.91
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.