Human Gene THAP10 (uc002asv.3)
  Description: Homo sapiens THAP domain containing 10 (THAP10), mRNA.
RefSeq Summary (NM_020147): This gene encodes a member of a family of proteins sharing an N-terminal Thanatos-associated domain. The Thanatos-associated domain contains a zinc finger signature similar to DNA-binding domains. This gene is part of a bidirectional gene pair on the long arm of chromosome 15 that is regulated by estrogen and may play a role in breast cancer. [provided by RefSeq, Nov 2010].
Transcript (Including UTRs)
   Position: hg19 chr15:71,173,681-71,184,772 Size: 11,092 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr15:71,174,793-71,184,611 Size: 9,819 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:71,173,681-71,184,772)mRNA (may differ from genome)Protein (257 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
OMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: THA10_HUMAN
DESCRIPTION: RecName: Full=THAP domain-containing protein 10;
SIMILARITY: Contains 1 THAP-type zinc finger.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.36 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 106.10 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.11161-0.460 Picture PostScript Text
3' UTR -219.961112-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR006612 - Znf_C2CH

Pfam Domains:
PF05485 - THAP domain

ModBase Predicted Comparative 3D Structure on Q9P2Z0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006357 regulation of transcription from RNA polymerase II promoter


-  Descriptions from all associated GenBank mRNAs
  BC027857 - Homo sapiens THAP domain containing 10, mRNA (cDNA clone MGC:34264 IMAGE:5222191), complete cds.
BC072414 - Homo sapiens THAP domain containing 10, mRNA (cDNA clone MGC:87938 IMAGE:6167441), complete cds.
AL360202 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 511235.
JD350885 - Sequence 331909 from Patent EP1572962.
JD200236 - Sequence 181260 from Patent EP1572962.
JD338746 - Sequence 319770 from Patent EP1572962.
JD157339 - Sequence 138363 from Patent EP1572962.
JD437650 - Sequence 418674 from Patent EP1572962.
JD305262 - Sequence 286286 from Patent EP1572962.
JD564053 - Sequence 545077 from Patent EP1572962.
JD360007 - Sequence 341031 from Patent EP1572962.
JD301878 - Sequence 282902 from Patent EP1572962.
AK313472 - Homo sapiens cDNA, FLJ94019.
CU693296 - Synthetic construct Homo sapiens gateway clone IMAGE:100016908 5' read THAP10 mRNA.
DQ890927 - Synthetic construct clone IMAGE:100003557; FLH167587.01X; RZPDo839C1090D THAP domain containing 10 (THAP10) gene, encodes complete protein.
KJ894360 - Synthetic construct Homo sapiens clone ccsbBroadEn_03754 THAP10 gene, encodes complete protein.
DQ894089 - Synthetic construct Homo sapiens clone IMAGE:100008549; FLH263654.01L; RZPDo839C1189D THAP domain containing 10 (THAP10) gene, encodes complete protein.
EU176528 - Synthetic construct Homo sapiens clone IMAGE:100011645; FLH264006.01L; RZPDo839C11245D THAP domain containing 10 (THAP10) gene, encodes complete protein.
JD178499 - Sequence 159523 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: B2R8R0, NM_020147, NP_064532, Q9P2Z0, THA10_HUMAN
UCSC ID: uc002asv.3
RefSeq Accession: NM_020147
Protein: Q9P2Z0 (aka THA10_HUMAN or THAA_HUMAN)
CCDS: CCDS10237.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020147.3
exon count: 3CDS single in 3' UTR: no RNA size: 2119
ORF size: 774CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1748.00frame shift in genome: no % Coverage: 96.60
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.