Human Gene NEO1 (uc002avn.4)
Description: Homo sapiens neogenin 1 (NEO1), transcript variant 3, mRNA.
RefSeq Summary (NM_002499): This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010].
Transcript (Including UTRs)
Position: hg19 chr15:73,344,825-73,597,547 Size: 252,723 Total Exon Count: 28 Strand: +
Coding Region
Position: hg19 chr15:73,345,017-73,595,037 Size: 250,021 Coding Exon Count: 28
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): NEO1
CDC HuGE Published Literature: NEO1
Positive Disease Associations: Body Fat Distribution
Related Studies: Body Fat Distribution , , .
[PubMed 0 ]
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003961 - Fibronectin_type3
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR010560 - Neogenin_C
Pfam Domains: PF00041 - Fibronectin type III domain
PF00047 - Immunoglobulin domain
PF06583 - Neogenin C-terminus
PF07679 - Immunoglobulin I-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain
SCOP Domains: 48726 - Immunoglobulin
49265 - Fibronectin type III
ModBase Predicted Comparative 3D Structure on B7ZKN0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
LF208525 - JP 2014500723-A/16028: Polycomb-Associated Non-Coding RNAs.LF213955 - JP 2014500723-A/21458: Polycomb-Associated Non-Coding RNAs.U61262 - Human neogenin mRNA, complete cds.U72391 - Human neogenin mRNA, complete cds.BC117161 - Homo sapiens neogenin homolog 1 (chicken), mRNA (cDNA clone MGC:150770 IMAGE:40125712), complete cds.BC143270 - Homo sapiens neogenin homolog 1 (chicken), mRNA (cDNA clone MGC:176789 IMAGE:9051772), complete cds.BC143271 - Homo sapiens neogenin homolog 1 (chicken), mRNA (cDNA clone MGC:176790 IMAGE:9051773), complete cds.BC143279 - Homo sapiens cDNA clone IMAGE:9051781, containing frame-shift errors.AB528479 - Synthetic construct DNA, clone: pF1KE1062, Homo sapiens NEO1 gene for neogenin homolog 1, without stop codon, in Flexi system.MA449532 - JP 2018138019-A/21458: Polycomb-Associated Non-Coding RNAs.MA444102 - JP 2018138019-A/16028: Polycomb-Associated Non-Coding RNAs.AB209412 - Homo sapiens mRNA for neogenin homolog 1 variant protein.JD462599 - Sequence 443623 from Patent EP1572962.JD125552 - Sequence 106576 from Patent EP1572962.JD395375 - Sequence 376399 from Patent EP1572962.JD258905 - Sequence 239929 from Patent EP1572962.JD408692 - Sequence 389716 from Patent EP1572962.DQ581077 - Homo sapiens piRNA piR-49189, complete sequence.LF377316 - JP 2014500723-A/184819: Polycomb-Associated Non-Coding RNAs.LF377311 - JP 2014500723-A/184814: Polycomb-Associated Non-Coding RNAs.LF377304 - JP 2014500723-A/184807: Polycomb-Associated Non-Coding RNAs.MA612893 - JP 2018138019-A/184819: Polycomb-Associated Non-Coding RNAs.MA612888 - JP 2018138019-A/184814: Polycomb-Associated Non-Coding RNAs.MA612881 - JP 2018138019-A/184807: Polycomb-Associated Non-Coding RNAs.LF377298 - JP 2014500723-A/184801: Polycomb-Associated Non-Coding RNAs.LF377297 - JP 2014500723-A/184800: Polycomb-Associated Non-Coding RNAs.LF377295 - JP 2014500723-A/184798: Polycomb-Associated Non-Coding RNAs.LF377292 - JP 2014500723-A/184795: Polycomb-Associated Non-Coding RNAs.LF377291 - JP 2014500723-A/184794: Polycomb-Associated Non-Coding RNAs.LF377290 - JP 2014500723-A/184793: Polycomb-Associated Non-Coding RNAs.LF377288 - JP 2014500723-A/184791: Polycomb-Associated Non-Coding RNAs.LF377282 - JP 2014500723-A/184785: Polycomb-Associated Non-Coding RNAs.LF377281 - JP 2014500723-A/184784: Polycomb-Associated Non-Coding RNAs.LF377280 - JP 2014500723-A/184783: Polycomb-Associated Non-Coding RNAs.LF377279 - JP 2014500723-A/184782: Polycomb-Associated Non-Coding RNAs.LF377278 - JP 2014500723-A/184781: Polycomb-Associated Non-Coding RNAs.LF377275 - JP 2014500723-A/184778: Polycomb-Associated Non-Coding RNAs.JD440268 - Sequence 421292 from Patent EP1572962.JD190209 - Sequence 171233 from Patent EP1572962.LF377268 - JP 2014500723-A/184771: Polycomb-Associated Non-Coding RNAs.JD253692 - Sequence 234716 from Patent EP1572962.JD163821 - Sequence 144845 from Patent EP1572962.LF377267 - JP 2014500723-A/184770: Polycomb-Associated Non-Coding RNAs.JD440693 - Sequence 421717 from Patent EP1572962.LF377266 - JP 2014500723-A/184769: Polycomb-Associated Non-Coding RNAs.JD250753 - Sequence 231777 from Patent EP1572962.AL355708 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 44260.AL390182 - Homo sapiens mRNA; cDNA DKFZp547A066 (from clone DKFZp547A066).AL359597 - Homo sapiens mRNA; cDNA DKFZp547B146 (from clone DKFZp547B146).LF377265 - JP 2014500723-A/184768: Polycomb-Associated Non-Coding RNAs.DQ578639 - Homo sapiens piRNA piR-46751, complete sequence.MA612875 - JP 2018138019-A/184801: Polycomb-Associated Non-Coding RNAs.MA612874 - JP 2018138019-A/184800: Polycomb-Associated Non-Coding RNAs.MA612872 - JP 2018138019-A/184798: Polycomb-Associated Non-Coding RNAs.MA612869 - JP 2018138019-A/184795: Polycomb-Associated Non-Coding RNAs.MA612868 - JP 2018138019-A/184794: Polycomb-Associated Non-Coding RNAs.MA612867 - JP 2018138019-A/184793: Polycomb-Associated Non-Coding RNAs.MA612865 - JP 2018138019-A/184791: Polycomb-Associated Non-Coding RNAs.MA612859 - JP 2018138019-A/184785: Polycomb-Associated Non-Coding RNAs.MA612858 - JP 2018138019-A/184784: Polycomb-Associated Non-Coding RNAs.MA612857 - JP 2018138019-A/184783: Polycomb-Associated Non-Coding RNAs.MA612856 - JP 2018138019-A/184782: Polycomb-Associated Non-Coding RNAs.MA612855 - JP 2018138019-A/184781: Polycomb-Associated Non-Coding RNAs.MA612852 - JP 2018138019-A/184778: Polycomb-Associated Non-Coding RNAs.MA612845 - JP 2018138019-A/184771: Polycomb-Associated Non-Coding RNAs.MA612844 - JP 2018138019-A/184770: Polycomb-Associated Non-Coding RNAs.MA612843 - JP 2018138019-A/184769: Polycomb-Associated Non-Coding RNAs.MA612842 - JP 2018138019-A/184768: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04514 - Cell adhesion molecules (CAMs)
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AB528479.1
exon count:
28 CDS single in 3' UTR:
no
RNA size:
4379
ORF size:
4365 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
8930.00 frame shift in genome:
no
% Coverage:
99.61
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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