Description: Homo sapiens RGM domain family, member A (RGMA), transcript variant 5, mRNA. RefSeq Summary (NM_001166288): This gene encodes a member of the repulsive guidance molecule family. The encoded protein is a glycosylphosphatidylinositol-anchored glycoprotein that functions as an axon guidance protein in the developing and adult central nervous system. This protein may also function as a tumor suppressor in some cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]. Transcript (Including UTRs) Position: hg19 chr15:93,586,636-93,616,939 Size: 30,304 Total Exon Count: 5 Strand: - Coding Region Position: hg19 chr15:93,588,228-93,595,540 Size: 7,313 Coding Exon Count: 2
ID:RGMA_HUMAN DESCRIPTION: RecName: Full=Repulsive guidance molecule A; AltName: Full=RGM domain family member A; Flags: Precursor; FUNCTION: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. SUBUNIT: Interacts with NEO1, BMP2 and BMP4 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). SIMILARITY: Belongs to the repulsive guidance molecule (RGM) family.
Body Height Caroline S Fox et al. BMC medical genetics 2007, Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project., BMC medical genetics.
[PubMed 17903300]
Adiposity traits are associated with SNPs on the Affymetrix 100K SNP GeneChip. Replication of these initial findings is necessary. These data will serve as a resource for replication as more genes become identified with BMI and WC.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96B86
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0010975 regulation of neuron projection development GO:0030509 BMP signaling pathway GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048681 negative regulation of axon regeneration
US Server
