Human Gene PDPK1 (uc002cqv.1)
Description: Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDPK1), transcript variant 3, mRNA.
Transcript (Including UTRs)
Position: hg19 chr16:2,606,897-2,634,065 Size: 27,169 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr16:2,607,761-2,633,733 Size: 25,973 Coding Exon Count: 9
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: PDPK2_HUMAN
DESCRIPTION: RecName: Full=Putative 3-phosphoinositide-dependent protein kinase 2; EC=2.7.11.1;
FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity).CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity).PTM: Phosphorylated on tyrosine and serine/threonine (By similarity).SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily.SIMILARITY: Contains 1 protein kinase domain.CAUTION: Could be the product of a pseudogene.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PDPK1
CDC HuGE Published Literature: PDPK1
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
C059514
resveratrol
D004317
Doxorubicin
D008070
Lipopolysaccharides
D014108
Tosylphenylalanyl Chloromethyl Ketone
C105934
celecoxib
C028474
1,4-bis(2-(3,5-dichloropyridyloxy))benzene
C016403
2,4-dinitrotoluene
C023514
2,6-dinitrotoluene
C518576
2-methylbutyric acid 4-((1,3)dioxan-5-ylmethoxyimino)-8-(2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl -7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthyl)heptanoate
C009505
4,4'-diaminodiphenylmethane
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011009 - Kinase-like_dom
IPR000719 - Prot_kinase_cat_dom
IPR017441 - Protein_kinase_ATP_BS
IPR002290 - Ser/Thr_dual-sp_kinase_dom
IPR008271 - Ser/Thr_kinase_AS
Pfam Domains: PF00069 - Protein kinase domain
PF07714 - Protein tyrosine kinase
PF14531 - Kinase-like
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q6A1A2
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AB209835 - Homo sapiens mRNA for 3-phosphoinositide dependent protein kinase-1 variant protein.BC006339 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:12726 IMAGE:4079551), complete cds.BC012103 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:20087 IMAGE:4561371), complete cds.AK131060 - Homo sapiens cDNA FLJ29026 fis, clone PRS04322, highly similar to 3-phosphoinositide dependent protein kinase-1 (EC 2.7.1.37).AK222581 - Homo sapiens mRNA for 3-phosphoinositide dependent protein kinase-1 variant, clone: CAS01142.AF017995 - Homo sapiens 3-phosphoinositide dependent protein kinase-1 (PDK1) mRNA, complete cds.Y15056 - Homo sapiens mRNA for PkB kinase.BC033494 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone MGC:35290 IMAGE:5176294), complete cds.AB463382 - Synthetic construct DNA, clone: pF1KB8111, Homo sapiens PDPK1 gene for 3-phosphoinositide dependent protein kinase-1, without stop codon, in Flexi system.DQ892297 - Synthetic construct clone IMAGE:100004927; FLH184990.01X; RZPDo839E01146D 3-phosphoinositide dependent protein kinase-1 (PDPK1) gene, encodes complete protein.DQ895496 - Synthetic construct Homo sapiens clone IMAGE:100009956; FLH184986.01L; RZPDo839E01145D 3-phosphoinositide dependent protein kinase-1 (PDPK1) gene, encodes complete protein.GQ129441 - Synthetic construct Homo sapiens clone HAIB:100068473; DKFZo004C0334 3-phosphoinositide dependent protein kinase-1 protein (PDPK1) gene, partial cds.EU832784 - Synthetic construct Homo sapiens clone HAIB:100067813; DKFZo008C0333 3-phosphoinositide dependent protein kinase-1 protein (PDPK1) gene, encodes complete protein.CU689632 - Synthetic construct Homo sapiens gateway clone IMAGE:100019354 5' read PDPK1 mRNA.KJ891774 - Synthetic construct Homo sapiens clone ccsbBroadEn_01168 PDPK1 gene, encodes complete protein.KJ905256 - Synthetic construct Homo sapiens clone ccsbBroadEn_14741 PDPK1 gene, encodes complete protein.CR536517 - Homo sapiens full open reading frame cDNA clone RZPDo834D0722D for gene PDPK1, 3-phosphoinositide dependent protein kinase-1; complete cds, incl. stopcodon.BC040324 - Homo sapiens 3-phosphoinositide dependent protein kinase-1, mRNA (cDNA clone IMAGE:4830546), with apparent retained intron.AJ785968 - Homo sapiens mRNA for PDPK2 protein.AK293900 - Homo sapiens cDNA FLJ59188 complete cds, highly similar to 3-phosphoinositide-dependent protein kinase 1(EC 2.7.11.1).JD021934 - Sequence 2958 from Patent EP1572962.JD036280 - Sequence 17304 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa03320 - PPAR signaling pathwayhsa04150 - mTOR signaling pathwayhsa04510 - Focal adhesionhsa04910 - Insulin signaling pathwayhsa04960 - Aldosterone-regulated sodium reabsorptionhsa05213 - Endometrial cancerhsa05215 - Prostate cancerhsa05223 - Non-small cell lung cancer
BioCarta from NCI Cancer Genome Anatomy Project h_eif4Pathway - Regulation of eIF4e and p70 S6 Kinase
h_mTORPathway - mTOR Signaling Pathway
h_ptdinsPathway - Phosphoinositides and their downstream targets.
h_igf1mtorpathway - Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
h_gsk3Pathway - Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
h_ptenPathway - PTEN dependent cell cycle arrest and apoptosis
h_aktPathway - AKT Signaling Pathway
Other Names for This Gene
Alternate Gene Symbols: AJ785968, NM_001261816, NP_001248745, PDPK2, PDPK2_HUMAN, Q6A1A2UCSC ID: uc002cqv.1RefSeq Accession: NM_001261816
Protein: Q6A1A2
(aka PDPK2_HUMAN)
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AJ785968.1
exon count:
9 CDS single in 3' UTR:
no
RNA size:
2387
ORF size:
1191 CDS single in intron:
no
Alignment % ID:
99.79
txCdsPredict score:
1610.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
2
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
1286 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.