Human Gene ZSCAN32 (uc002cux.4)
  Description: Homo sapiens zinc finger and SCAN domain containing 32 (ZSCAN32), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr16:3,432,085-3,451,013 Size: 18,929 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr16:3,432,852-3,447,554 Size: 14,703 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:3,432,085-3,451,013)mRNA (may differ from genome)Protein (696 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMGIPubMedTreefam
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6WMU8_HUMAN
DESCRIPTION: SubName: Full=Zinc finger protein 434; SubName: Full=cDNA FLJ77128, highly similar to Homo sapiens zinc finger protein 434 (ZNF434) mRNA;
SIMILARITY: Contains 1 SCAN box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.57 RPKM in Testis
Total median expression: 142.00 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.30259-0.310 Picture PostScript Text
3' UTR -206.59767-0.269 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF02023 - SCAN domain
PF13837 - Myb/SANT-like DNA-binding domain
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q6WMU8
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Descriptions from all associated GenBank mRNAs
  AK000424 - Homo sapiens cDNA FLJ20417 fis, clone KAT02301.
BC017015 - Homo sapiens zinc finger protein 434, mRNA (cDNA clone IMAGE:3846413), with apparent retained intron.
AY279347 - Homo sapiens zinc finger protein 434 (ZNF434) mRNA, complete cds.
AY261676 - Homo sapiens zinc finger protein mRNA, complete cds.
JD280008 - Sequence 261032 from Patent EP1572962.
JD432738 - Sequence 413762 from Patent EP1572962.
AK056463 - Homo sapiens cDNA FLJ31901 fis, clone NT2RP7004204, weakly similar to ZINC FINGER PROTEIN MLZ-4.
AK291213 - Homo sapiens cDNA FLJ77128 complete cds, highly similar to Homo sapiens zinc finger protein 434 (ZNF434) mRNA.
AK301586 - Homo sapiens cDNA FLJ54764 complete cds, highly similar to Zinc finger protein 434.
JD217841 - Sequence 198865 from Patent EP1572962.
JD061670 - Sequence 42694 from Patent EP1572962.
JD073385 - Sequence 54409 from Patent EP1572962.
JD564792 - Sequence 545816 from Patent EP1572962.
JD401374 - Sequence 382398 from Patent EP1572962.
DQ570596 - Homo sapiens piRNA piR-30708, complete sequence.
JD199126 - Sequence 180150 from Patent EP1572962.
JD074446 - Sequence 55470 from Patent EP1572962.
JD044678 - Sequence 25702 from Patent EP1572962.
JD342644 - Sequence 323668 from Patent EP1572962.
BC002859 - Homo sapiens zinc finger protein 434, mRNA (cDNA clone MGC:4179 IMAGE:3638050), complete cds.
AY279348 - Homo sapiens truncated zinc finger protein 434 isoform (ZNF434) mRNA, complete cds.
AK303338 - Homo sapiens cDNA FLJ56278 complete cds, highly similar to Zinc finger protein 434.
AK299070 - Homo sapiens cDNA FLJ54133 complete cds, highly similar to Zinc finger protein 434.
KJ902718 - Synthetic construct Homo sapiens clone ccsbBroadEn_12112 ZNF434 gene, encodes complete protein.
CU678248 - Synthetic construct Homo sapiens gateway clone IMAGE:100018626 5' read ZNF434 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: BC002859, NM_017810, NP_060280, Q6WMU8, Q6WMU8_HUMAN, ZNF434
UCSC ID: uc002cux.4
RefSeq Accession: NM_017810
Protein: Q6WMU8 CCDS: CCDS66921.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: BC002859.2
exon count: 7CDS single in 3' UTR: no RNA size: 1491
ORF size: 2091CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4267.00frame shift in genome: no % Coverage: 98.26
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.