Description: Homo sapiens glycoprotein 2 (zymogen granule membrane) (GP2), transcript variant 2, mRNA. RefSeq Summary (NM_001502): This gene encodes an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. The encoded protein binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]. Transcript (Including UTRs) Position: hg19 chr16:20,321,811-20,338,835 Size: 17,025 Total Exon Count: 11 Strand: - Coding Region Position: hg19 chr16:20,322,545-20,337,753 Size: 15,209 Coding Exon Count: 10
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): GP2 CDC HuGE Published Literature: GP2 Positive Disease Associations: Diabetes Mellitus, Type 1 Related Studies:
Diabetes Mellitus, Type 1 Jeffrey C Barrett et al. Nature genetics 2009, Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes., Nature genetics.
[PubMed 19430480]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00100 - Zona pellucida-like domain
ModBase Predicted Comparative 3D Structure on P55259-3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.