Description: Homo sapiens bromodomain containing 7 (BRD7), transcript variant 1, mRNA. RefSeq Summary (NM_001173984): This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]. Transcript (Including UTRs) Position: hg19 chr16:50,352,929-50,402,845 Size: 49,917 Total Exon Count: 17 Strand: - Coding Region Position: hg19 chr16:50,353,122-50,402,685 Size: 49,564 Coding Exon Count: 17
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): BRD7 CDC HuGE Published Literature: BRD7 Positive Disease Associations: Inflammatory Bowel Diseases Related Studies:
Inflammatory Bowel Diseases Richard H Duerr et al. Science (New York, N.Y.) 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene., Science (New York, N.Y.).
[PubMed 17068223]
Inflammatory Bowel Diseases Richard H Duerr et al. Science (New York, N.Y.) 2006, A genome-wide association study identifies IL23R as an inflammatory bowel disease gene., Science (New York, N.Y.).
[PubMed 17068223]
MalaCards Disease Associations
MalaCards Gene Search: BRD7 Diseases sorted by gene-association score: pharynx cancer (2)
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00439 - Bromodomain PF12024 - Domain of unknown function (DUF3512)
ModBase Predicted Comparative 3D Structure on Q9NPI1-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
