Human Gene FTO (uc002ehs.3)
|
|
Sequence and Links to Tools and Databases
|
|
Primer design for this transcript
|
|
Genetic Association Studies of Complex Diseases and Disorders
|
|
Genetic Association Database (archive): FTO
CDC HuGE Published Literature: FTO
Positive Disease Associations:
, Adiposity
, adiposity and blood pressure
, Biomedical quantitative traits
, Birth Weight|Cardiovascular Diseases
, BMI
, body mass index
, Body Weight
, C-reactive protein blood levels
, Cell Adhesion Molecules
, Coronary Disease
, Diabetes Mellitus, Type 2
, Diabetes Mellitus, Type 2|Obesity
, diabetes, type 2
, Menarche
, Metabolic Syndrome X
, obesity
, obesity (early onset extreme)
, obesity (extreme)
, obesity-related traits
, Potassium
, type 2 diabetes
, waist circumference
, Waist-Hip Ratio
, weight
Related Studies: -
Tuomo Rankinen , et al. Obesity 2010 18(2):322-6, FTO genotype is associated with exercise training-induced changes in body composition., Obesity 2010 18(2):322-6.
[PubMed 19543202]
- Adiposity
Tuomas O Kilpelainen et al. Nature genetics 2011, Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile., Nature genetics.
[PubMed 21706003]
- adiposity and blood pressure
Zdenka Pausova , et al. Circulation 2009 2(3):260-9, A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians., Circulation 2009 2(3):260-9.
[PubMed 20031594]
These results suggest that, in a French Canadian founder population, FTO may increase not only risk for obesity, as demonstrated in other populations, but also for hypertension.
  more ... click here to view the complete list
| |
|
|
MalaCards Disease Associations
|
|
MalaCards Gene Search: FTO
Diseases sorted by gene-association score: growth retardation, developmental delay, facial dysmorphism* (1550), obesity bmiq14* (550), growth retardation, developmental delay, coarse facies, and early death* (500), obesity (19), overnutrition (15), morbid obesity (6), suppression amblyopia (4), cranioectodermal dysplasia 1 (3), acquired metabolic disease (1) * = Manually curated disease association
| |
|
|
Comparative Toxicogenomics Database (CTD)
|
|
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
|
|
Microarray Expression Data
|
|
Press "+" in the title bar above to open this section.
| |
|
|
Orthologous Genes in Other Species
|
|
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
| | | | | |
|
| |
|
|
Descriptions from all associated GenBank mRNAs
|
|
LF384420 - JP 2014500723-A/191923: Polycomb-Associated Non-Coding RNAs. AK096554 - Homo sapiens cDNA FLJ39235 fis, clone OCBBF2007829, highly similar to Mus musculus mRNA for fatso protein. AB051539 - Homo sapiens KIAA1752 mRNA for KIAA1752 protein. AK295196 - Homo sapiens cDNA FLJ61116 complete cds. BC148442 - Synthetic construct Homo sapiens clone IMAGE:100015377, MGC:183011 fat mass and obesity associated (FTO) mRNA, encodes complete protein. BC153032 - Synthetic construct Homo sapiens clone IMAGE:100016381, MGC:184272 fat mass and obesity associated (FTO) mRNA, encodes complete protein. BC132892 - Homo sapiens fat mass and obesity associated, mRNA (cDNA clone IMAGE:40146914), complete cds. BC137091 - Homo sapiens fat mass and obesity associated, mRNA (cDNA clone IMAGE:9021088), complete cds. BC030798 - Homo sapiens fat mass and obesity associated, mRNA (cDNA clone IMAGE:3457322), complete cds. BC003583 - Homo sapiens fat mass and obesity associated, mRNA (cDNA clone IMAGE:3353414), complete cds. KJ906309 - Synthetic construct Homo sapiens clone ccsbBroadEn_15979 FTO gene, encodes complete protein. MA619997 - JP 2018138019-A/191923: Polycomb-Associated Non-Coding RNAs. JD362624 - Sequence 343648 from Patent EP1572962. JD456260 - Sequence 437284 from Patent EP1572962. JD121082 - Sequence 102106 from Patent EP1572962. JD299810 - Sequence 280834 from Patent EP1572962. JD438552 - Sequence 419576 from Patent EP1572962. JD540233 - Sequence 521257 from Patent EP1572962. U79260 - Human clone 23745 mRNA, complete cds. BC001284 - Homo sapiens fat mass and obesity associated, mRNA (cDNA clone IMAGE:3453653). JD225060 - Sequence 206084 from Patent EP1572962. JD439667 - Sequence 420691 from Patent EP1572962. JD264815 - Sequence 245839 from Patent EP1572962. JD389386 - Sequence 370410 from Patent EP1572962. JD550475 - Sequence 531499 from Patent EP1572962. JD225895 - Sequence 206919 from Patent EP1572962. JD502509 - Sequence 483533 from Patent EP1572962. JD262750 - Sequence 243774 from Patent EP1572962. JD134629 - Sequence 115653 from Patent EP1572962. JD174238 - Sequence 155262 from Patent EP1572962. JD414077 - Sequence 395101 from Patent EP1572962. JD302076 - Sequence 283100 from Patent EP1572962. JD170934 - Sequence 151958 from Patent EP1572962. JD311406 - Sequence 292430 from Patent EP1572962. JD080706 - Sequence 61730 from Patent EP1572962. JD484380 - Sequence 465404 from Patent EP1572962. JD399369 - Sequence 380393 from Patent EP1572962. JD566814 - Sequence 547838 from Patent EP1572962. JD384796 - Sequence 365820 from Patent EP1572962. JD374550 - Sequence 355574 from Patent EP1572962. JD409296 - Sequence 390320 from Patent EP1572962. JD489176 - Sequence 470200 from Patent EP1572962. JD489177 - Sequence 470201 from Patent EP1572962. JD567027 - Sequence 548051 from Patent EP1572962. JD567026 - Sequence 548050 from Patent EP1572962. JD551149 - Sequence 532173 from Patent EP1572962. JD566085 - Sequence 547109 from Patent EP1572962. JD566084 - Sequence 547108 from Patent EP1572962. JD508036 - Sequence 489060 from Patent EP1572962. JD064538 - Sequence 45562 from Patent EP1572962. JD064537 - Sequence 45561 from Patent EP1572962. JD333258 - Sequence 314282 from Patent EP1572962. JD296855 - Sequence 277879 from Patent EP1572962. JD488167 - Sequence 469191 from Patent EP1572962. JD524309 - Sequence 505333 from Patent EP1572962. JD257308 - Sequence 238332 from Patent EP1572962. JD488093 - Sequence 469117 from Patent EP1572962. JD414695 - Sequence 395719 from Patent EP1572962. JD306793 - Sequence 287817 from Patent EP1572962. JD414697 - Sequence 395721 from Patent EP1572962. JD505787 - Sequence 486811 from Patent EP1572962. JD107542 - Sequence 88566 from Patent EP1572962. JD186683 - Sequence 167707 from Patent EP1572962. JD475678 - Sequence 456702 from Patent EP1572962. JD271885 - Sequence 252909 from Patent EP1572962. JD465191 - Sequence 446215 from Patent EP1572962. JD418279 - Sequence 399303 from Patent EP1572962. JD390687 - Sequence 371711 from Patent EP1572962.
| |
|
|
Other Names for This Gene
|
|
Alternate Gene Symbols: BC003583 UCSC ID: uc002ehs.3 RefSeq Accession: NM_001080432
| |
|
|
Gene Model Information
|
|
category:
| nearCoding
| nonsense-mediated-decay:
| no
| RNA accession:
| BC003583.1
|
exon count:
| 3 | CDS single in 3' UTR:
| no
| RNA size:
| 2833 |
ORF size:
| 0 | CDS single in intron:
| no
| Alignment % ID:
| 99.89 |
txCdsPredict score:
| 528.50 | frame shift in genome:
| no
| % Coverage:
| 98.59 |
has start codon:
| no
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| no
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
|
Click here
for a detailed description of the fields of the table above.
| |
|
|
Methods, Credits, and Use Restrictions
|
|
Click here
for details on how this gene model was made and data restrictions if any.
| |
|
|
|