Human Gene DPEP3 (uc002evc.4)
Description: Homo sapiens dipeptidase 3 (DPEP3), transcript variant 1, mRNA.
Transcript (Including UTRs)
Position: hg19 chr16:68,009,566-68,014,452 Size: 4,887 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr16:68,009,668-68,014,358 Size: 4,691 Coding Exon Count: 10
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: DPEP3_HUMAN
DESCRIPTION: RecName: Full=Dipeptidase 3; EC=3.4.13.19; Flags: Precursor;
FUNCTION: Probable metalloprotease which hydrolyzes cystinyl-bis- glycine. May be involved in meiosis (By similarity).CATALYTIC ACTIVITY: Hydrolysis of dipeptides.COFACTOR: Zinc (By similarity).ENZYME REGULATION: Inhibited by L-penicillamine (By similarity).SUBUNIT: Homodimer; disulfide-linked (By similarity).SUBCELLULAR LOCATION: Membrane; Lipid-anchor, GPI-anchor (By similarity).SIMILARITY: Belongs to the peptidase M19 family.SEQUENCE CAUTION: Sequence=AAH57789.1; Type=Erroneous initiation; Sequence=BAG51910.1; Type=Erroneous initiation; Sequence=CAC15385.1; Type=Erroneous initiation; Sequence=EAW83198.1; Type=Erroneous initiation;
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): DPEP3
CDC HuGE Published Literature: DPEP3
Positive Disease Associations: Cholesterol, HDL
, Lipoproteins, HDL
Related Studies: Cholesterol, HDL Chiara Sabatti et al. Nature genetics 2009, Genome-wide association analysis of metabolic traits in a birth cohort from a founder population., Nature genetics.
[PubMed 19060910 ]
Lipoproteins, HDL , , .
[PubMed 0 ]
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
Common Gene Haplotype Alleles
Press "+" in the title bar above to open this section.
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
Press "+" in the title bar above to open this section.
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000180 - Pept_M19_AS
IPR008257 - Peptidase_M19
Pfam Domains: PF01244 - Membrane dipeptidase (Peptidase family M19)
SCOP Domains: 51556 - Metallo-dependent hydrolases
ModBase Predicted Comparative 3D Structure on Q9H4B8
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC037243 - Homo sapiens dipeptidase 3, mRNA (cDNA clone IMAGE:5171919).AJ291679 - Homo sapiens mRNA for putative metallopeptidase (family M19).AY358390 - Homo sapiens clone DNA59817 QPTG834 (UNQ834) mRNA, complete cds.HM005556 - Homo sapiens clone HTL-S-16 testis secretory sperm-binding protein Li 211a mRNA, complete cds.LP896040 - Sequence 904 from Patent EP3253886.AK057401 - Homo sapiens cDNA FLJ32839 fis, clone TESTI2003311, highly similar to Dipeptidase 3 precursor (EC 3.4.13.19).BC057789 - Homo sapiens dipeptidase 3, mRNA (cDNA clone MGC:71629 IMAGE:5297958), complete cds.JD309806 - Sequence 290830 from Patent EP1572962.JD061217 - Sequence 42241 from Patent EP1572962.KJ903064 - Synthetic construct Homo sapiens clone ccsbBroadEn_12458 DPEP3 gene, encodes complete protein.AB590471 - Synthetic construct DNA, clone: pFN21AE1957, Homo sapiens DPEP3 gene for dipeptidase 3, without stop codon, in Flexi system.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: B3KQ48, DPEP3_HUMAN, NM_022357, NP_071752, Q6PEZ5, Q6UXE4, Q9H4B8, UNQ834/PRO1772UCSC ID: uc002evc.4RefSeq Accession: NM_022357
Protein: Q9H4B8
(aka DPEP3_HUMAN)
CCDS: CCDS10856.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_022357.3
exon count:
10 CDS single in 3' UTR:
no
RNA size:
1756
ORF size:
1542 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
3284.00 frame shift in genome:
no
% Coverage:
98.97
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
Click here
for a detailed description of the fields of the table above.
Methods, Credits, and Use Restrictions
Click here
for details on how this gene model was made and data restrictions if any.