Description: Homo sapiens cyclin-dependent kinase 10 (CDK10), transcript variant f, non-coding RNA. RefSeq Summary (NM_052987): The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]. Transcript (Including UTRs) Position: hg19 chr16:89,753,076-89,762,772 Size: 9,697 Total Exon Count: 12 Strand: + Coding Region Position: hg19 chr16:89,757,014-89,762,183 Size: 5,170 Coding Exon Count: 11
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): CDK10 CDC HuGE Published Literature: CDK10 Positive Disease Associations: Hair Color
, Heart Failure
, Melanoma Related Studies:
Hair Color Jiali Han et al. PLoS genetics 2008, A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation., PLoS genetics.
[PubMed 18483556]
Melanoma Jennifer H Barrett et al. Nature genetics 2011, Genome-wide association study identifies three new melanoma susceptibility loci., Nature genetics.
[PubMed 21983787]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00069 - Protein kinase domain PF07714 - Protein tyrosine kinase
SCOP Domains: 56112 - Protein kinase-like (PK-like)
ModBase Predicted Comparative 3D Structure on Q15131-4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
