Description: Homo sapiens active BCR-related (ABR), transcript variant 2, mRNA. RefSeq Summary (NM_001159746): This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]. Transcript (Including UTRs) Position: hg19 chr17:913,969-995,100 Size: 81,132 Total Exon Count: 9 Strand: - Coding Region Position: hg19 chr17:913,970-995,087 Size: 81,118 Coding Exon Count: 9
ModBase Predicted Comparative 3D Structure on Q6ZT60
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007165 signal transduction GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043547 positive regulation of GTPase activity
U01147 - Human guanine nucleotide regulatory protein (ABR) mRNA, complete cds. AK124547 - Homo sapiens cDNA FLJ42556 fis, clone BRACE3005760, highly similar to Active breakpoint cluster region-related protein. AK126882 - Homo sapiens cDNA FLJ44934 fis, clone BRAMY3017920, highly similar to Active breakpoint cluster region-related protein. AK302682 - Homo sapiens cDNA FLJ60982 complete cds, highly similar to Active breakpoint cluster region-related protein. BC172517 - Synthetic construct Homo sapiens clone IMAGE:100069211, MGC:199222 active BCR-related gene (ABR) mRNA, encodes complete protein. BC156483 - Synthetic construct Homo sapiens clone IMAGE:100063042, MGC:190674 active BCR-related gene (ABR) mRNA, encodes complete protein. AB384846 - Synthetic construct DNA, clone: pF1KB3726, Homo sapiens ABR gene for active breakpoint cluster region-related protein, complete cds, without stop codon, in Flexi system. AK299909 - Homo sapiens cDNA FLJ54747 complete cds, highly similar to Active breakpoint cluster region-related protein. AK295191 - Homo sapiens cDNA FLJ60543 complete cds, highly similar to Active breakpoint cluster region-related protein. AK300336 - Homo sapiens cDNA FLJ53654 complete cds, highly similar to Active breakpoint cluster region-related protein. AK127851 - Homo sapiens cDNA FLJ45954 fis, clone PLACE7009936, highly similar to Active breakpoint cluster region-related protein. AK307827 - Homo sapiens cDNA, FLJ97775.
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