ID:TUSC5_HUMAN DESCRIPTION: RecName: Full=Tumor suppressor candidate 5; AltName: Full=Dispanin subfamily B member 1; Short=DSPB1; AltName: Full=Interferon-induced transmembrane domain-containing protein D3; AltName: Full=Protein located at seventeen-p-thirteen point three 1; FUNCTION: May be involved in fat metabolism (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus. DEVELOPMENTAL STAGE: Expressed in fetal brain. SIMILARITY: Belongs to the CD225/Dispanin family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04505 - Interferon-induced transmembrane protein
ModBase Predicted Comparative 3D Structure on Q8IXB3
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0009607 response to biotic stimulus GO:0032869 cellular response to insulin stimulus GO:0044381 glucose import in response to insulin stimulus GO:0045026 plasma membrane fusion GO:0072659 protein localization to plasma membrane GO:0099638 endosome to plasma membrane protein transport