Description: Homo sapiens diphthamide biosynthesis 1 (DPH1), mRNA. RefSeq Summary (NM_001383): The protein encoded by this gene is an enzyme involved in the biosynthesis of diphthamide, a modified histidine found only in elongation factor-2 (EEF2). Diphthamide residues in EEF2 are targeted for ADP-ribosylation by diphtheria toxin and Pseudomonas exotoxin A. Defects in this gene have been associated with both ovarian cancer and autosomal recessive intellectual disability with short stature, craniofacial, and ectodermal anomalies. [provided by RefSeq, Oct 2016]. Transcript (Including UTRs) Position: hg19 chr17:1,933,431-1,946,725 Size: 13,295 Total Exon Count: 13 Strand: + Coding Region Position: hg19 chr17:1,933,464-1,945,151 Size: 11,688 Coding Exon Count: 12
ID:I3L1H5_HUMAN DESCRIPTION: RecName: Full=Diphthamide biosynthesis protein 1; Flags: Fragment; SIMILARITY: Belongs to the DPH1/DPH2 family. DPH1 subfamily. CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01866 - Putative diphthamide synthesis protein
ModBase Predicted Comparative 3D Structure on I3L1H5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.