Description: Homo sapiens sedoheptulokinase (SHPK), mRNA. RefSeq Summary (NM_013276): The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:3,511,556-3,539,616 Size: 28,061 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr17:3,513,854-3,539,513 Size: 25,660 Coding Exon Count: 7
ID:SHPK_HUMAN DESCRIPTION: RecName: Full=Sedoheptulokinase; Short=SHK; EC=2.7.1.14; AltName: Full=Carbohydrate kinase-like protein; FUNCTION: Acts as a modulator of macrophage activation through control of glucose metabolism (By similarity). CATALYTIC ACTIVITY: ATP + sedoheptulose = ADP + sedoheptulose 7- phosphate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.06 mM for sedoheptulose; pH dependence: Optimum pH is 8.5; SUBCELLULAR LOCATION: Cytoplasm (By similarity). TISSUE SPECIFICITY: Strongly expressed in liver, kidney and pancreas. Expressed at lower levels in placenta and heart. Very weakly expressed in lung and brain. INDUCTION: Down-regulated by LPS. SIMILARITY: Belongs to the FGGY kinase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UHJ6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.