Description: Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. RefSeq Summary (NM_012452): The protein encoded by this gene is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It interacts with calcium-modulator and cyclophilin ligand (CAML). The protein induces activation of the transcription factors NFAT, AP1, and NF-kappa-B and plays a crucial role in humoral immunity by interacting with a TNF ligand. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:16,842,398-16,875,402 Size: 33,005 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr17:16,842,861-16,875,389 Size: 32,529 Coding Exon Count: 4
aneurysm, intracranial Inoue, K. et al. 2006, Search on Chromosome 17 Centromere Reveals TNFRSF13B as a Susceptibility Gene for Intracranial Aneurysm. A Preliminary Study, Circulation 2006.
[PubMed 16618819]
We propose that TNFRSF13B is one of the susceptibility genes for IA.
Blood Proteins Yoichiro Kamatani et al. Nature genetics 2010, Genome-wide association study of hematological and biochemical traits in a Japanese population., Nature genetics.
[PubMed 20139978]
Blood Proteins Wael Osman et al. PloS one 2012, Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese., PloS one.
[PubMed 22558069]
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14836-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303298 - Homo sapiens cDNA FLJ52819 complete cds, highly similar to Tumor necrosis factor receptor superfamilymember 13B. AX772740 - Sequence 1 from Patent WO03045421. AF023614 - Homo sapiens transmembrane activator and CAML interactor (TACI) mRNA, complete cds. AX766384 - Sequence 1 from Patent WO03041730. AK097261 - Homo sapiens cDNA FLJ39942 fis, clone SPLEN2023024, highly similar to Macaca mulatta transmembrane activator (NF-AT) mRNA. JD254208 - Sequence 235232 from Patent EP1572962. AK223453 - Homo sapiens mRNA for tumor necrosis factor receptor 13B variant, clone: FCC114F06. JD437986 - Sequence 419010 from Patent EP1572962. JD064277 - Sequence 45301 from Patent EP1572962. JD441090 - Sequence 422114 from Patent EP1572962. JD186242 - Sequence 167266 from Patent EP1572962. JD178949 - Sequence 159973 from Patent EP1572962. JD442170 - Sequence 423194 from Patent EP1572962. JD204928 - Sequence 185952 from Patent EP1572962. JD178952 - Sequence 159976 from Patent EP1572962. JD064249 - Sequence 45273 from Patent EP1572962. JD445451 - Sequence 426475 from Patent EP1572962. JD064276 - Sequence 45300 from Patent EP1572962. JD103757 - Sequence 84781 from Patent EP1572962. JD066037 - Sequence 47061 from Patent EP1572962. JD064250 - Sequence 45274 from Patent EP1572962. JD437368 - Sequence 418392 from Patent EP1572962. JD103604 - Sequence 84628 from Patent EP1572962. JD186222 - Sequence 167246 from Patent EP1572962. JD064020 - Sequence 45044 from Patent EP1572962. JD330766 - Sequence 311790 from Patent EP1572962. JD043493 - Sequence 24517 from Patent EP1572962. JD202846 - Sequence 183870 from Patent EP1572962. JD214242 - Sequence 195266 from Patent EP1572962. JD064248 - Sequence 45272 from Patent EP1572962. JD436276 - Sequence 417300 from Patent EP1572962. JD483635 - Sequence 464659 from Patent EP1572962. JD317006 - Sequence 298030 from Patent EP1572962. JD442070 - Sequence 423094 from Patent EP1572962. JD331248 - Sequence 312272 from Patent EP1572962. JD442009 - Sequence 423033 from Patent EP1572962. JD064268 - Sequence 45292 from Patent EP1572962. JD178951 - Sequence 159975 from Patent EP1572962. JD063852 - Sequence 44876 from Patent EP1572962. BC109392 - Homo sapiens tumor necrosis factor receptor superfamily, member 13B, mRNA (cDNA clone MGC:133214 IMAGE:40030781), complete cds. JD331227 - Sequence 312251 from Patent EP1572962. JD077119 - Sequence 58143 from Patent EP1572962. JD178496 - Sequence 159520 from Patent EP1572962. JD332985 - Sequence 314009 from Patent EP1572962. JD471484 - Sequence 452508 from Patent EP1572962. JD342729 - Sequence 323753 from Patent EP1572962. JD445340 - Sequence 426364 from Patent EP1572962. JD108476 - Sequence 89500 from Patent EP1572962. JD492695 - Sequence 473719 from Patent EP1572962. AY302137 - Homo sapiens transmembrane activator and CAML interactor (TNFRSF13B) mRNA, complete cds; alternatively spliced. AK313302 - Homo sapiens cDNA, FLJ93815, highly similar to Homo sapiens tumor necrosis factor receptor superfamily, member 13B (TNFRSF13B), mRNA. KJ902345 - Synthetic construct Homo sapiens clone ccsbBroadEn_11739 TNFRSF13B gene, encodes complete protein. KR711554 - Synthetic construct Homo sapiens clone CCSBHm_00025940 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711555 - Synthetic construct Homo sapiens clone CCSBHm_00025943 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711556 - Synthetic construct Homo sapiens clone CCSBHm_00025946 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR711557 - Synthetic construct Homo sapiens clone CCSBHm_00025951 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712223 - Synthetic construct Homo sapiens clone CCSBHm_00900178 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712231 - Synthetic construct Homo sapiens clone CCSBHm_00900189 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. KR712232 - Synthetic construct Homo sapiens clone CCSBHm_00900190 TNFRSF13B (TNFRSF13B) mRNA, encodes complete protein. AK301032 - Homo sapiens cDNA FLJ52770 complete cds, highly similar to Tumor necrosis factor receptor superfamily member 13B.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04060 - Cytokine-cytokine receptor interaction hsa04672 - Intestinal immune network for IgA production hsa05340 - Primary immunodeficiency
Reactome (by CSHL, EBI, and GO)
Protein O14836 (Reactome details) participates in the following event(s):