Description: Homo sapiens RAS, dexamethasone-induced 1 (RASD1), transcript variant 1, mRNA. RefSeq Summary (NM_016084): This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2011]. Transcript (Including UTRs) Position: hg19 chr17:17,397,753-17,399,709 Size: 1,957 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr17:17,398,439-17,399,495 Size: 1,057 Coding Exon Count: 2
ID:RASD1_HUMAN DESCRIPTION: RecName: Full=Dexamethasone-induced Ras-related protein 1; AltName: Full=Activator of G-protein signaling 1; Flags: Precursor; FUNCTION: Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). SUBUNIT: Forms a ternary complex with CAPON and NOS1. Component of a complex, at least composed of APBB1, RASD1/DEXRAS1 and APP. Interacts with APBB1/FE65 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential). Cytoplasm, perinuclear region (By similarity). Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in a variety of tissues including heart, cardiovascular tissues, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, gastrointestinal and reproductive tissues. INDUCTION: By dexamethasone. PTM: S-nitrosylation stimulates guanine-nucleotide exchange activity. SIMILARITY: Belongs to the small GTPase superfamily. RasD family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y272
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.