Human Gene TMEM98 (uc002hhr.3)
  Description: Homo sapiens transmembrane protein 98 (TMEM98), transcript variant 2, mRNA.
RefSeq Summary (NM_001033504): This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014].
Transcript (Including UTRs)
   Position: hg19 chr17:31,254,928-31,268,667 Size: 13,740 Total Exon Count: 7 Strand: +
Coding Region
   Position: hg19 chr17:31,258,547-31,268,011 Size: 9,465 Coding Exon Count: 6 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesGO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:31,254,928-31,268,667)mRNA (may differ from genome)Protein (226 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMalacardsMGI
neXtProtOMIMPubMedTreefamUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM98_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 98; AltName: Full=Protein TADA1;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM98 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM98
CDC HuGE Published Literature: TMEM98
Positive Disease Associations: Bipolar Disorder
Related Studies:
  1. Bipolar Disorder
    , , . [PubMed 0]

-  MalaCards Disease Associations
  MalaCards Gene Search: TMEM98
Diseases sorted by gene-association score: nanophthalmos 4* (1239), microphthalmia* (206)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 42.58 RPKM in Ovary
Total median expression: 488.74 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -224.80382-0.588 Picture PostScript Text
3' UTR -210.20656-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF13324 - Grap2 and cyclin-D-interacting

ModBase Predicted Comparative 3D Structure on Q9Y2Y6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details   Gene Details 
Gene Sorter   Gene Sorter 
  Ensembl WormBase 
  Protein Sequence Protein Sequence 
  Alignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL117619 - Homo sapiens mRNA; cDNA DKFZp564K1964 (from clone DKFZp564K1964).
AK313569 - Homo sapiens cDNA, FLJ94133.
AY358573 - Homo sapiens clone DNA56050 ETVV536 (UNQ536) mRNA, complete cds.
JD407106 - Sequence 388130 from Patent EP1572962.
BC000526 - Homo sapiens transmembrane protein 98, mRNA (cDNA clone MGC:8605 IMAGE:2961267), complete cds.
AF132000 - Homo sapiens TADA1 protein mRNA, complete cds.
JD563483 - Sequence 544507 from Patent EP1572962.
JD551852 - Sequence 532876 from Patent EP1572962.
JD508292 - Sequence 489316 from Patent EP1572962.
AM392645 - Synthetic construct Homo sapiens clone IMAGE:100002231 for hypothetical protein (TMEM98 gene).
KJ893511 - Synthetic construct Homo sapiens clone ccsbBroadEn_02905 TMEM98 gene, encodes complete protein.
AB528260 - Synthetic construct DNA, clone: pF1KE0182, Homo sapiens TMEM98 gene for transmembrane protein 98, without stop codon, in Flexi system.
CR457125 - Homo sapiens full open reading frame cDNA clone RZPDo834A078D for gene DKFZP564K1964, DKFZP564K1964 protein; complete cds, incl. stopcodon.
BC106911 - Homo sapiens transmembrane protein 98, mRNA (cDNA clone IMAGE:40031873), partial cds.
JD535715 - Sequence 516739 from Patent EP1572962.
JD080378 - Sequence 61402 from Patent EP1572962.
JD411281 - Sequence 392305 from Patent EP1572962.
JD100777 - Sequence 81801 from Patent EP1572962.
JD057770 - Sequence 38794 from Patent EP1572962.
JD409436 - Sequence 390460 from Patent EP1572962.
JD358447 - Sequence 339471 from Patent EP1572962.
JD553174 - Sequence 534198 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: E1P631, NM_001033504, NP_056359, Q9UFK2, Q9Y2Y6, TMM98_HUMAN, UNQ536/PRO1079
UCSC ID: uc002hhr.3
RefSeq Accession: NM_001033504
Protein: Q9Y2Y6 (aka TMM98_HUMAN)
CCDS: CCDS11274.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001033504.1
exon count: 7CDS single in 3' UTR: no RNA size: 1732
ORF size: 681CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1311.50frame shift in genome: no % Coverage: 99.25
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.