Description: Homo sapiens chemokine (C-C motif) ligand 3-like 1 (CCL3L3), mRNA. RefSeq Summary (NM_021006): This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]. Transcript (Including UTRs) Position: hg19 chr17:34,522,268-34,524,156 Size: 1,889 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr17:34,522,685-34,524,072 Size: 1,388 Coding Exon Count: 3
ID:CL3L1_HUMAN DESCRIPTION: RecName: Full=C-C motif chemokine 3-like 1; AltName: Full=G0/G1 switch regulatory protein 19-2; AltName: Full=LD78-beta(1-70); AltName: Full=PAT 464.2; AltName: Full=Small-inducible cytokine A3-like 1; AltName: Full=Tonsillar lymphocyte LD78 beta protein; Contains: RecName: Full=LD78-beta(3-70); Contains: RecName: Full=LD78-beta(5-70); Flags: Precursor; FUNCTION: Chemotactic for lymphocytes and monocytes. Is a ligand for CCR1, CCR3 and CCR5. Is an inhibitor of HIV-1-infection. The processed form LD78-beta(3-70) shows a 20-fold to 30-fold higher chemotactic activity and is a very potent inhibitor of HIV-1- infection. LD78-beta(3-70) is also a ligand for CCR1, CCR3 and CCR5. SUBCELLULAR LOCATION: Secreted. PTM: The N-terminal processed forms LD78-beta(3-70) and LD78- beta(5-70) are produced by proteolytic cleavage after secretion from peripheral blood monocytes. The cleavage to yield LD78- beta(3-70) is probably achieved by DPP4. POLYMORPHISM: The copy number of the CCL3L1 gene varies among individuals; most individuals have 1-6 copies in the diploid genome, although rare individuals have zero or more than 6 copies. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P16619
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.