Human Gene TMEM92 (uc002iqn.2)
  Description: Homo sapiens transmembrane protein 92 (TMEM92), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr17:48,348,767-48,358,846 Size: 10,080 Total Exon Count: 6 Strand: +
Coding Region
   Position: hg19 chr17:48,351,863-48,356,669 Size: 4,807 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:48,348,767-48,358,846)mRNA (may differ from genome)Protein (159 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TMM92_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 92; Flags: Precursor;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMEM92
CDC HuGE Published Literature: TMEM92
Positive Disease Associations: Lipoproteins
Related Studies:
  1. Lipoproteins
    , , . [PubMed 0]

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.69 RPKM in Small Intestine - Terminal Ileum
Total median expression: 28.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.70110-0.261 Picture PostScript Text
3' UTR -890.672177-0.409 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF11669 - WW domain-binding protein 1

ModBase Predicted Comparative 3D Structure on Q6UXU6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AY358204 - Homo sapiens clone DNA131647 SQAW5801 (UNQ5801) mRNA, complete cds.
AK090637 - Homo sapiens cDNA FLJ33318 fis, clone BNGH42007594.
AX746552 - Sequence 77 from Patent EP1308459.
JD123065 - Sequence 104089 from Patent EP1572962.
BC064507 - Homo sapiens transmembrane protein 92, mRNA (cDNA clone MGC:71131 IMAGE:6455254), complete cds.
KJ900347 - Synthetic construct Homo sapiens clone ccsbBroadEn_09741 TMEM92 gene, encodes complete protein.
JD095149 - Sequence 76173 from Patent EP1572962.
JD545685 - Sequence 526709 from Patent EP1572962.
JD099566 - Sequence 80590 from Patent EP1572962.
JD067167 - Sequence 48191 from Patent EP1572962.
JD235507 - Sequence 216531 from Patent EP1572962.
JD365601 - Sequence 346625 from Patent EP1572962.
JD227168 - Sequence 208192 from Patent EP1572962.
JD421828 - Sequence 402852 from Patent EP1572962.
JD541199 - Sequence 522223 from Patent EP1572962.
JD458816 - Sequence 439840 from Patent EP1572962.
JD455178 - Sequence 436202 from Patent EP1572962.
JD507274 - Sequence 488298 from Patent EP1572962.
JD052624 - Sequence 33648 from Patent EP1572962.
JD367405 - Sequence 348429 from Patent EP1572962.
JD152680 - Sequence 133704 from Patent EP1572962.
JD480789 - Sequence 461813 from Patent EP1572962.
JD283964 - Sequence 264988 from Patent EP1572962.
JD231521 - Sequence 212545 from Patent EP1572962.
JD335451 - Sequence 316475 from Patent EP1572962.
JD118664 - Sequence 99688 from Patent EP1572962.
JD099893 - Sequence 80917 from Patent EP1572962.
JD183039 - Sequence 164063 from Patent EP1572962.
JD050697 - Sequence 31721 from Patent EP1572962.
JD480704 - Sequence 461728 from Patent EP1572962.
JD104390 - Sequence 85414 from Patent EP1572962.
JD424355 - Sequence 405379 from Patent EP1572962.
JD202715 - Sequence 183739 from Patent EP1572962.
JD363439 - Sequence 344463 from Patent EP1572962.
JD544438 - Sequence 525462 from Patent EP1572962.
JD038495 - Sequence 19519 from Patent EP1572962.
JD454673 - Sequence 435697 from Patent EP1572962.
JD352798 - Sequence 333822 from Patent EP1572962.
JD497089 - Sequence 478113 from Patent EP1572962.
JD475332 - Sequence 456356 from Patent EP1572962.
JD130845 - Sequence 111869 from Patent EP1572962.
JD324324 - Sequence 305348 from Patent EP1572962.
JD414020 - Sequence 395044 from Patent EP1572962.
JD180994 - Sequence 162018 from Patent EP1572962.
JD349339 - Sequence 330363 from Patent EP1572962.
JD347899 - Sequence 328923 from Patent EP1572962.
JD081262 - Sequence 62286 from Patent EP1572962.
JD170888 - Sequence 151912 from Patent EP1572962.
JD146269 - Sequence 127293 from Patent EP1572962.
JD304149 - Sequence 285173 from Patent EP1572962.
JD130940 - Sequence 111964 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_001168215, NP_694961, Q6UXU6, Q8NBF0, TMM92_HUMAN, UNQ5801/PRO19608
UCSC ID: uc002iqn.2
RefSeq Accession: NM_001168215
Protein: Q6UXU6 (aka TMM92_HUMAN)
CCDS: CCDS11562.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001168215.1
exon count: 6CDS single in 3' UTR: no RNA size: 2782
ORF size: 480CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1160.00frame shift in genome: no % Coverage: 99.46
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.