Description: Homo sapiens CD79b molecule, immunoglobulin-associated beta (CD79B), transcript variant 1, mRNA. RefSeq Summary (NM_000626): The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:62,006,098-62,009,704 Size: 3,607 Total Exon Count: 6 Strand: - Coding Region Position: hg19 chr17:62,006,586-62,009,621 Size: 3,036 Coding Exon Count: 6
ID:CD79B_HUMAN DESCRIPTION: RecName: Full=B-cell antigen receptor complex-associated protein beta chain; AltName: Full=B-cell-specific glycoprotein B29; AltName: Full=Ig-beta; AltName: Full=Immunoglobulin-associated B29 protein; AltName: CD_antigen=CD79b; Flags: Precursor; FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Following antigen binding, the BCR has been shown to translocate from detergent-soluble regions of the cell membrane to lipid rafts although signal transduction through the complex can also occur outside lipid rafts (By similarity). TISSUE SPECIFICITY: B-cells. PTM: Phosphorylated on tyrosine upon B-cell activation by SRC-type Tyr-kinases such as BLK, LYN and SYK. DISEASE: Defects in CD79B are the cause of agammaglobulinemia type 6 (AGM6) [MIM:612692]. It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain. SIMILARITY: Contains 1 ITAM domain. WEB RESOURCE: Name=CD79Bbase; Note=CD79B mutation db; URL="http://bioinf.uta.fi/CD79Bbase/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40259
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF209399 - JP 2014500723-A/16902: Polycomb-Associated Non-Coding RNAs. AK222954 - Homo sapiens mRNA for CD79B antigen isoform 1 precursor variant, clone: HSI00794. M80461 - Human B29 mRNA, complete cds. BC032651 - Homo sapiens CD79b molecule, immunoglobulin-associated beta, mRNA (cDNA clone MGC:45004 IMAGE:5504755), complete cds. BC002975 - Homo sapiens CD79b molecule, immunoglobulin-associated beta, mRNA (cDNA clone MGC:2173 IMAGE:3542354), complete cds. AK223210 - Homo sapiens mRNA for CD79B antigen isoform 1 precursor variant, clone: SPL04753. M89957 - Homo sapiens cell surface glycoprotein (IGB) mRNA, complete cds. AX775815 - Sequence 85 from Patent WO03048202. AX775817 - Sequence 87 from Patent WO03048202. JD123892 - Sequence 104916 from Patent EP1572962. JD062261 - Sequence 43285 from Patent EP1572962. JD378529 - Sequence 359553 from Patent EP1572962. JD165375 - Sequence 146399 from Patent EP1572962. JD387213 - Sequence 368237 from Patent EP1572962. JD052887 - Sequence 33911 from Patent EP1572962. JD123154 - Sequence 104178 from Patent EP1572962. JD154095 - Sequence 135119 from Patent EP1572962. JD228372 - Sequence 209396 from Patent EP1572962. JD566174 - Sequence 547198 from Patent EP1572962. JD121525 - Sequence 102549 from Patent EP1572962. S52229 - Ig-beta/B29=membrane immunoglobulin beta chain [human, B cells, mRNA, 786 nt]. JD159763 - Sequence 140787 from Patent EP1572962. JD201029 - Sequence 182053 from Patent EP1572962. JD118846 - Sequence 99870 from Patent EP1572962. JD176792 - Sequence 157816 from Patent EP1572962. X83539 - H.sapiens B29 mRNA for Ig-beta, splice variant. AK313583 - Homo sapiens cDNA, FLJ94147, highly similar to Homo sapiens CD79B antigen (immunoglobulin-associated beta) (CD79B), transcript variant 1, mRNA. KJ896572 - Synthetic construct Homo sapiens clone ccsbBroadEn_05966 CD79B gene, encodes complete protein. KR710895 - Synthetic construct Homo sapiens clone CCSBHm_00017961 CD79B (CD79B) mRNA, encodes complete protein. S79249 - Ig-beta/B29=CD79b {alternatively spliced} [human, B cells, mRNA Partial, 375 nt]. BC030210 - Homo sapiens CD79b molecule, immunoglobulin-associated beta, mRNA (cDNA clone IMAGE:5209928), complete cds. KJ901327 - Synthetic construct Homo sapiens clone ccsbBroadEn_10721 CD79B gene, encodes complete protein. JD408704 - Sequence 389728 from Patent EP1572962. JD221223 - Sequence 202247 from Patent EP1572962. JD409365 - Sequence 390389 from Patent EP1572962. JD203705 - Sequence 184729 from Patent EP1572962. JD214945 - Sequence 195969 from Patent EP1572962. MA444976 - JP 2018138019-A/16902: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04662 - B cell receptor signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_bcrmolecule - B Cell Receptor Complex h_ctcfPathway - CTCF: First Multivalent Nuclear Factor h_bcrPathway - BCR Signaling Pathway
Reactome (by CSHL, EBI, and GO)
Protein P40259 (Reactome details) participates in the following event(s):
R-HSA-983696 The Immunoglobulin of the BCR binds antigen R-HSA-983700 SYK binds the activated BCR R-HSA-5690740 CD22 binds B-cell receptor R-HSA-983703 p-6Y-SYK phosphorylates BLNK (SLP65) R-HSA-983707 SYK autophosphorylates at the activated BCR R-HSA-5690702 LYN phosphorylates CD22 R-HSA-5690701 SHP1 binds p-CD22 R-HSA-1112666 BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers R-HSA-983705 Signaling by the B Cell Receptor (BCR) R-HSA-5690714 CD22 mediated BCR regulation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System