Description: Homo sapiens CDC42 effector protein (Rho GTPase binding) 4 (CDC42EP4), mRNA. RefSeq Summary (NM_012121): The product of this gene is a member of the CDC42-binding protein family. Members of this family interact with Rho family GTPases and regulate the organization of the actin cytoskeleton. This protein has been shown to bind both CDC42 and TC10 GTPases in a GTP-dependent manner. When overexpressed in fibroblasts, this protein was able to induce pseudopodia formation, which suggested a role in inducing actin filament assembly and cell shape control. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr17:71,279,763-71,307,054 Size: 27,292 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr17:71,281,569-71,282,639 Size: 1,071 Coding Exon Count: 1
ID:BORG4_HUMAN DESCRIPTION: RecName: Full=Cdc42 effector protein 4; AltName: Full=Binder of Rho GTPases 4; FUNCTION: Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation, when overexpressed in fibroblasts. SUBUNIT: Interacts with CDC42 and RHOQ, in a GTP-dependent manner (By similarity). SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein. Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Not detected in any of the adult tissues tested. May be expressed only in fetal or embryonic tissues. SIMILARITY: Belongs to the BORG/CEP family. SIMILARITY: Contains 1 CRIB domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H3Q1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
