Human Gene MIF4GD (uc002jnp.3)
  Description: Homo sapiens MIF4G domain containing (MIF4GD), transcript variant 2, mRNA.
RefSeq Summary (NM_020679): This gene encodes a protein which interacts with the N-terminus of the stem-loop binding protein (SLBP) and the 3' end of histone mRNA. This interaction facilitates the activation of histone mRNA translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011].
Transcript (Including UTRs)
   Position: hg19 chr17:73,262,310-73,267,311 Size: 5,002 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr17:73,262,821-73,266,276 Size: 3,456 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersMalaCardsCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:73,262,310-73,267,311)mRNA (may differ from genome)Protein (256 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMalacards
MGIOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MIF4GD
Diseases sorted by gene-association score: retinitis pigmentosa 70 (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 314.78 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -74.70137-0.545 Picture PostScript Text
3' UTR -163.66511-0.320 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF02854 - MIF4G domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on A9UHW6-2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF209419 - JP 2014500723-A/16922: Polycomb-Associated Non-Coding RNAs.
AF225422 - Homo sapiens AD023 mRNA, complete cds.
BC033759 - Homo sapiens MIF4G domain containing, mRNA (cDNA clone MGC:45027 IMAGE:5215495), complete cds.
EU287989 - Homo sapiens SLBP-interacting protein 1 (SLIP1) mRNA, complete cds.
JD303011 - Sequence 284035 from Patent EP1572962.
JD546405 - Sequence 527429 from Patent EP1572962.
JD095542 - Sequence 76566 from Patent EP1572962.
JD243537 - Sequence 224561 from Patent EP1572962.
JD100726 - Sequence 81750 from Patent EP1572962.
JD297626 - Sequence 278650 from Patent EP1572962.
JD433171 - Sequence 414195 from Patent EP1572962.
LF328402 - JP 2014500723-A/135905: Polycomb-Associated Non-Coding RNAs.
JD502761 - Sequence 483785 from Patent EP1572962.
JD367992 - Sequence 349016 from Patent EP1572962.
AK300711 - Homo sapiens cDNA FLJ51624 complete cds, moderately similar to Rattus norvegicus MIF4G domain containing (Mif4gd), mRNA.
LF328403 - JP 2014500723-A/135906: Polycomb-Associated Non-Coding RNAs.
DQ600465 - Homo sapiens piRNA piR-38531, complete sequence.
DQ890815 - Synthetic construct clone IMAGE:100003445; FLH166172.01X; RZPDo839D0886D MIF4G domain containing (MIF4GD) gene, encodes complete protein.
CU689726 - Synthetic construct Homo sapiens gateway clone IMAGE:100016903 5' read MIF4GD mRNA.
KJ894424 - Synthetic construct Homo sapiens clone ccsbBroadEn_03818 MIF4GD gene, encodes complete protein.
DQ893971 - Synthetic construct Homo sapiens clone IMAGE:100008431; FLH166168.01L; RZPDo839D0885D MIF4G domain containing (MIF4GD) gene, encodes complete protein.
KU178731 - Homo sapiens MIF4G domain containing isoform 1 (MIF4GD) mRNA, partial cds.
KU178732 - Homo sapiens MIF4G domain containing isoform 2 (MIF4GD) mRNA, partial cds, alternatively spliced.
KU178733 - Homo sapiens MIF4G domain containing isoform 3 (MIF4GD) mRNA, partial cds, alternatively spliced.
KU178734 - Homo sapiens MIF4G domain containing isoform 4 (MIF4GD) mRNA, partial cds, alternatively spliced.
LF328405 - JP 2014500723-A/135908: Polycomb-Associated Non-Coding RNAs.
LF328408 - JP 2014500723-A/135911: Polycomb-Associated Non-Coding RNAs.
LF328412 - JP 2014500723-A/135915: Polycomb-Associated Non-Coding RNAs.
JD239953 - Sequence 220977 from Patent EP1572962.
JD461636 - Sequence 442660 from Patent EP1572962.
MA563979 - JP 2018138019-A/135905: Polycomb-Associated Non-Coding RNAs.
MA563980 - JP 2018138019-A/135906: Polycomb-Associated Non-Coding RNAs.
MA563982 - JP 2018138019-A/135908: Polycomb-Associated Non-Coding RNAs.
MA563985 - JP 2018138019-A/135911: Polycomb-Associated Non-Coding RNAs.
MA563989 - JP 2018138019-A/135915: Polycomb-Associated Non-Coding RNAs.
MA444996 - JP 2018138019-A/16922: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A9UHW6-2, NM_020679, NP_065730, SLIP1
UCSC ID: uc002jnp.3
RefSeq Accession: NM_020679
Protein: A9UHW6-2, splice isoform of A9UHW6 CCDS: CCDS11719.1, CCDS58598.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_020679.3
exon count: 7CDS single in 3' UTR: no RNA size: 1441
ORF size: 771CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 1739.00frame shift in genome: no % Coverage: 98.47
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.