Human Gene EXOC7 (uc002jqq.3)
Description: Homo sapiens exocyst complex component 7 (EXOC7), transcript variant 1, mRNA.
RefSeq Summary (NM_001013839): The protein encoded by this gene is a component of the exocyst complex. The exocyst complex plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. The encoded protein is required for assembly of the exocyst complex and docking of the complex to the plasma membrane. The encoded protein may also play a role in pre-mRNA splicing through interactions with pre-mRNA-processing factor 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Nov 2011].
Transcript (Including UTRs)
Position: hg19 chr17:74,077,086-74,099,868 Size: 22,783 Total Exon Count: 19 Strand: -
Coding Region
Position: hg19 chr17:74,079,729-74,099,773 Size: 20,045 Coding Exon Count: 19
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF03081 - Exo70 exocyst complex subunit
ModBase Predicted Comparative 3D Structure on Q9UPT5-1
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
AK000718 - Homo sapiens cDNA FLJ20711 fis, clone HUV01082.BC015165 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone IMAGE:3891713), complete cds.AK022552 - Homo sapiens cDNA FLJ12490 fis, clone NT2RM2001592, highly similar to Rattus norvegicus rexo70 mRNA.AK023832 - Homo sapiens cDNA FLJ13770 fis, clone PLACE4000269, highly similar to Rattus norvegicus rexo70 mRNA.AB028990 - Homo sapiens KIAA1067 mRNA for KIAA1067 protein.AL162005 - Homo sapiens mRNA; cDNA DKFZp434D2029 (from clone DKFZp434D2029).BX648435 - Homo sapiens mRNA; cDNA DKFZp686J04253 (from clone DKFZp686J04253).AK128278 - Homo sapiens cDNA FLJ46415 fis, clone THYMU3011717, moderately similar to Mus musculus EXO70 protein (Exo70) mRNA.JD544409 - Sequence 525433 from Patent EP1572962.JD307748 - Sequence 288772 from Patent EP1572962.AK024769 - Homo sapiens cDNA: FLJ21116 fis, clone CAS05539.KJ902315 - Synthetic construct Homo sapiens clone ccsbBroadEn_11709 EXOC7 gene, encodes complete protein.JD344171 - Sequence 325195 from Patent EP1572962.JD443923 - Sequence 424947 from Patent EP1572962.JD040016 - Sequence 21040 from Patent EP1572962.JD496655 - Sequence 477679 from Patent EP1572962.CU677223 - Synthetic construct Homo sapiens gateway clone IMAGE:100016850 5' read EXOC7 mRNA.JD221051 - Sequence 202075 from Patent EP1572962.JD545302 - Sequence 526326 from Patent EP1572962.JD480889 - Sequence 461913 from Patent EP1572962.JD473506 - Sequence 454530 from Patent EP1572962.JD485375 - Sequence 466399 from Patent EP1572962.JD060762 - Sequence 41786 from Patent EP1572962.JD041774 - Sequence 22798 from Patent EP1572962.JD502530 - Sequence 483554 from Patent EP1572962.JD231176 - Sequence 212200 from Patent EP1572962.JD418690 - Sequence 399714 from Patent EP1572962.JD335941 - Sequence 316965 from Patent EP1572962.JD387486 - Sequence 368510 from Patent EP1572962.JD045648 - Sequence 26672 from Patent EP1572962.JD317912 - Sequence 298936 from Patent EP1572962.JD204722 - Sequence 185746 from Patent EP1572962.JD089431 - Sequence 70455 from Patent EP1572962.JD298797 - Sequence 279821 from Patent EP1572962.JD372234 - Sequence 353258 from Patent EP1572962.JD487024 - Sequence 468048 from Patent EP1572962.BC018466 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone MGC:9876 IMAGE:3867492), complete cds.BX647763 - Homo sapiens mRNA; cDNA DKFZp686P1551 (from clone DKFZp686P1551).JD068885 - Sequence 49909 from Patent EP1572962.JD354479 - Sequence 335503 from Patent EP1572962.JD504703 - Sequence 485727 from Patent EP1572962.JD187111 - Sequence 168135 from Patent EP1572962.JD232973 - Sequence 213997 from Patent EP1572962.JD249147 - Sequence 230171 from Patent EP1572962.JD330177 - Sequence 311201 from Patent EP1572962.JD131210 - Sequence 112234 from Patent EP1572962.JD314048 - Sequence 295072 from Patent EP1572962.JD227949 - Sequence 208973 from Patent EP1572962.JD216381 - Sequence 197405 from Patent EP1572962.JD389103 - Sequence 370127 from Patent EP1572962.JD432306 - Sequence 413330 from Patent EP1572962.JD365960 - Sequence 346984 from Patent EP1572962.JD121821 - Sequence 102845 from Patent EP1572962.JD123320 - Sequence 104344 from Patent EP1572962.JD500346 - Sequence 481370 from Patent EP1572962.JD471454 - Sequence 452478 from Patent EP1572962.JD074960 - Sequence 55984 from Patent EP1572962.JD497986 - Sequence 479010 from Patent EP1572962.JD297694 - Sequence 278718 from Patent EP1572962.JD166856 - Sequence 147880 from Patent EP1572962.JD266372 - Sequence 247396 from Patent EP1572962.JD382530 - Sequence 363554 from Patent EP1572962.JD068296 - Sequence 49320 from Patent EP1572962.JD242317 - Sequence 223341 from Patent EP1572962.JD517195 - Sequence 498219 from Patent EP1572962.JD127119 - Sequence 108143 from Patent EP1572962.JD200648 - Sequence 181672 from Patent EP1572962.JD525527 - Sequence 506551 from Patent EP1572962.JD226712 - Sequence 207736 from Patent EP1572962.JD057294 - Sequence 38318 from Patent EP1572962.AK295871 - Homo sapiens cDNA FLJ58532 complete cds, highly similar to Exocyst complex component 7.JD278540 - Sequence 259564 from Patent EP1572962.JD233521 - Sequence 214545 from Patent EP1572962.AK098284 - Homo sapiens cDNA FLJ40965 fis, clone UTERU2012031, moderately similar to Rattus norvegicus rexo70 mRNA.AY869728 - Homo sapiens 2-5-3p (EXOC7) mRNA, partial cds.BC011045 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone MGC:16883 IMAGE:4215228), complete cds.AL834324 - Homo sapiens mRNA; cDNA DKFZp564B1282 (from clone DKFZp564B1282).JD051184 - Sequence 32208 from Patent EP1572962.JD027724 - Sequence 8748 from Patent EP1572962.JD019812 - Sequence 836 from Patent EP1572962.JD298044 - Sequence 279068 from Patent EP1572962.FJ457119 - Homo sapiens EXOC7 splice variant 5 (EXOC7) mRNA, complete cds, alternatively spliced.FJ457120 - Homo sapiens EXOC7 splice variant 6 (EXOC7) mRNA, complete cds, alternatively spliced.AB384100 - Synthetic construct DNA, clone: pF1KSDA1067, Homo sapiens EXOC7 gene for exocyst complex component 7, complete cds, without stop codon, in Flexi system.AK022397 - Homo sapiens cDNA FLJ12335 fis, clone MAMMA1002219, highly similar to Rattus norvegicus rexo70 mRNA.BC029432 - Homo sapiens exocyst complex component 7, mRNA (cDNA clone IMAGE:4093432), with apparent retained intron.
Biochemical and Signaling Pathways
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_001013839.2
exon count:
19 CDS single in 3' UTR:
no
RNA size:
4799
ORF size:
2055 CDS single in intron:
no
Alignment % ID:
100.00
txCdsPredict score:
4310.00 frame shift in genome:
no
% Coverage:
99.88
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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