Description: Homo sapiens progressive rod-cone degeneration (PRCD), transcript variant 1, mRNA. RefSeq Summary (NM_001077620): This gene is predominantly expressed in the retina, and mutations in this gene are the cause of autosomal recessive retinal degeneration in both humans and dogs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]. Transcript (Including UTRs) Position: hg19 chr17:74,536,121-74,541,458 Size: 5,338 Total Exon Count: 5 Strand: + Coding Region Position: hg19 chr17:74,536,224-74,538,656 Size: 2,433 Coding Exon Count: 3
ID:PRCD_HUMAN DESCRIPTION: RecName: Full=Progressive rod-cone degeneration protein; FUNCTION: Involved in vision. SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential). Cytoplasm. DISEASE: Defects in PRCD are the cause of retinitis pigmentosa type 36 (RP36) [MIM:610599]. A retinal dystrophy belonging to the group of pigmentary retinopathies. RP is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q00LT1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
