Human Gene GPS1 (uc002kdm.1)
  Description: Homo sapiens G protein pathway suppressor 1 (GPS1), transcript variant 1, mRNA.
RefSeq Summary (NM_212492): This gene is known to suppress G-protein and mitogen-activated signal transduction in mammalian cells. The encoded protein shares significant similarity with Arabidopsis FUS6, which is a regulator of light-mediated signal transduction in plant cells. [provided by RefSeq, Mar 2016].
Transcript (Including UTRs)
   Position: hg19 chr17:80,009,763-80,015,346 Size: 5,584 Total Exon Count: 14 Strand: +
Coding Region
   Position: hg19 chr17:80,011,165-80,015,003 Size: 3,839 Coding Exon Count: 12 

Page IndexSequence and LinksPrimersCTDGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:80,009,763-80,015,346)mRNA (may differ from genome)Protein (471 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCLynxMGIOMIM
PubMedTreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 54.74 RPKM in Testis
Total median expression: 1647.43 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -80.20178-0.451 Picture PostScript Text
3' UTR -166.60343-0.486 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019585 - 26S_proteasome_reg_su-Rpn7
IPR000717 - PCI_dom
IPR011990 - TPR-like_helical
IPR011991 - WHTH_trsnscrt_rep_DNA-bd

Pfam Domains:
PF01399 - PCI domain
PF10602 - 26S proteasome subunit RPN7

SCOP Domains:
46785 - "Winged helix" DNA-binding domain

ModBase Predicted Comparative 3D Structure on C9JFE4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0000338 protein deneddylation

Cellular Component:
GO:0008180 COP9 signalosome


-  Descriptions from all associated GenBank mRNAs
  LF209450 - JP 2014500723-A/16953: Polycomb-Associated Non-Coding RNAs.
U20285 - Human Gps1 (GPS1) mRNA, complete cds.
AK222508 - Homo sapiens mRNA, G protein pathway suppressor 1 isoform 2 variant, clone: adKA03519.
AK093283 - Homo sapiens cDNA FLJ35964 fis, clone TESTI2012592, highly similar to G PROTEIN PATHWAY SUPPRESSOR 1.
AX748031 - Sequence 1556 from Patent EP1308459.
AK026610 - Homo sapiens cDNA: FLJ22957 fis, clone KAT09963, highly similar to HSU20285 Human Gps1 (GPS1) mRNA.
AK225248 - Homo sapiens mRNA for G protein pathway suppressor 1 isoform 2 variant, clone: DMC00580.
BC000155 - Homo sapiens G protein pathway suppressor 1, mRNA (cDNA clone MGC:5330 IMAGE:2900944), complete cds.
AK297872 - Homo sapiens cDNA FLJ55804 complete cds, highly similar to COP9 signalosome complex subunit 1.
EU832397 - Synthetic construct Homo sapiens clone HAIB:100067426; DKFZo004D0628 G protein pathway suppressor 1 protein (GPS1) gene, encodes complete protein.
EU832312 - Synthetic construct Homo sapiens clone HAIB:100067341; DKFZo008D0627 G protein pathway suppressor 1 protein (GPS1) gene, encodes complete protein.
BC064503 - Homo sapiens G protein pathway suppressor 1, mRNA (cDNA clone MGC:71287 IMAGE:6572943), complete cds.
AK289435 - Homo sapiens cDNA FLJ75157 complete cds, highly similar to Homo sapiens G protein pathway suppressor 1, transcript variant 1, mRNA.
HQ258557 - Synthetic construct Homo sapiens clone IMAGE:100073060 G protein pathway suppressor 1 (GPS1), transcript variant 1 (GPS1) gene, encodes complete protein.
KJ891289 - Synthetic construct Homo sapiens clone ccsbBroadEn_00683 GPS1 gene, encodes complete protein.
AB209596 - Homo sapiens mRNA for G protein pathway suppressor 1 isoform 2 variant protein.
BT009834 - Homo sapiens G protein pathway suppressor 1 mRNA, complete cds.
JD090571 - Sequence 71595 from Patent EP1572962.
JD321774 - Sequence 302798 from Patent EP1572962.
JD152045 - Sequence 133069 from Patent EP1572962.
JD484816 - Sequence 465840 from Patent EP1572962.
JD189388 - Sequence 170412 from Patent EP1572962.
JD393449 - Sequence 374473 from Patent EP1572962.
JD151614 - Sequence 132638 from Patent EP1572962.
JD362758 - Sequence 343782 from Patent EP1572962.
MA445027 - JP 2018138019-A/16953: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: AK026610, C9JFE4, C9JFE4_HUMAN, hCG_1987516, NM_212492, NP_997657
UCSC ID: uc002kdm.1
RefSeq Accession: NM_212492
Protein: C9JFE4 CCDS: CCDS32774.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK026610.1
exon count: 14CDS single in 3' UTR: no RNA size: 1940
ORF size: 1416CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2621.00frame shift in genome: no % Coverage: 99.02
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.