Human Gene HCN2 (uc002lpe.3)
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: HCN2_HUMAN
DESCRIPTION: RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; AltName: Full=Brain cyclic nucleotide-gated channel 2; Short=BCNG-2;
FUNCTION: Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). SUBUNIT: The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming subunits. Heteromultimer with HCN1. Interacts with KCNE2 (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Highly expressed throughout the brain. Detected at low levels in heart. DOMAIN: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. MISCELLANEOUS: Inhibited by extracellular cesium ions. SIMILARITY: Belongs to the potassium channel HCN family. SIMILARITY: Contains 1 cyclic nucleotide-binding domain.
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Primer design for this transcript
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Genetic Association Studies of Complex Diseases and Disorders
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Genetic Association Database (archive): HCN2
CDC HuGE Published Literature: HCN2
Positive Disease Associations: seizures, febrile
Related Studies: - seizures, febrile
Ma, Y. N. et al. 2005, [Association between familial febrile convulsions and HCN2 gene], Zhonghua yi xue za zhi. 2005 Mar;85(10):663-6.
[PubMed 15932727]
HCN2 may not be a susceptibility gene for FC in Chinese population.
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MalaCards Disease Associations
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Comparative Toxicogenomics Database (CTD)
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Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure IPR018490 - cNMP-bd-like
IPR018488 - cNMP-bd_CS
IPR000595 - cNMP-bd_dom
IPR005821 - Ion_trans_dom
IPR013621 - Ion_trans_N
IPR003938 - K_chnl_volt-dep_EAG/ELK/ERG
IPR014710 - RmlC-like_jellyroll
Pfam Domains: PF00027 - Cyclic nucleotide-binding domain
PF00520 - Ion transport protein
PF08412 - Ion transport protein N-terminal
SCOP Domains: 51206 - cAMP-binding domain-like
81324 - Voltage-gated potassium channels
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q9UL51
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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AJ012582 - Homo sapiens mRNA for hyperpolarization-activated cation channel HCN2. AF065164 - Homo sapiens hyperpolarization-activated, cyclic nucleotide-gated channel 2 (HCN2) mRNA, complete cds. DQ854815 - Homo sapiens hyperpolarization-activated cyclic nucleotide-gated potassium channel 2 mRNA, partial cds. AB527443 - Synthetic construct DNA, clone: pF1KB7295, Homo sapiens HCN2 gene for hyperpolarization activated cyclic nucleotide-gated potassium channel 2, without stop codon, in Flexi system. BC118001 - Synthetic construct Homo sapiens clone IMAGE:40080842, MGC:133396 HCN2 protein (HCN2) mRNA, encodes complete protein. BC039619 - Homo sapiens hyperpolarization activated cyclic nucleotide-gated potassium channel 2, mRNA (cDNA clone IMAGE:5730201). AF064877 - Homo sapiens ion channel BCNG-2 mRNA, partial cds. DQ574370 - Homo sapiens piRNA piR-42482, complete sequence. JD419299 - Sequence 400323 from Patent EP1572962. JD470031 - Sequence 451055 from Patent EP1572962. JD111539 - Sequence 92563 from Patent EP1572962. JD416360 - Sequence 397384 from Patent EP1572962. JD475191 - Sequence 456215 from Patent EP1572962. JD076689 - Sequence 57713 from Patent EP1572962. JD405741 - Sequence 386765 from Patent EP1572962. JD395255 - Sequence 376279 from Patent EP1572962. JD399386 - Sequence 380410 from Patent EP1572962. JD128058 - Sequence 109082 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Other Names for This Gene
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Alternate Gene Symbols: BCNG2, HCN2_HUMAN, NM_001194, NP_001185, O60742, O60743, O75267, Q9UBS2, Q9UL51 UCSC ID: uc002lpe.3 RefSeq Accession: NM_001194
Protein: Q9UL51
(aka HCN2_HUMAN)
CCDS: CCDS12035.1
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Gene Model Information
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category:
| coding
| nonsense-mediated-decay:
| no
| RNA accession:
| NM_001194.3
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exon count:
| 8 | CDS single in 3' UTR:
| no
| RNA size:
| 3459 |
ORF size:
| 2670 | CDS single in intron:
| no
| Alignment % ID:
| 100.00 |
txCdsPredict score:
| 3826.00 | frame shift in genome:
| no
| % Coverage:
| 98.53 |
has start codon:
| yes
| stop codon in genome:
| no
| # of Alignments:
| 1 |
has end codon:
| yes
| retained intron:
| no
| # AT/AC introns
| 0 |
selenocysteine:
| no
| end bleed into intron:
| 0 | # strange splices:
| 0 |
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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