Human Gene TMPRSS9 (uc002lvv.1)
  Description: Homo sapiens transmembrane protease, serine 9 (TMPRSS9), mRNA.
RefSeq Summary (NM_182973): The protein encoded by this gene is a membrane-bound type II serine polyprotease that is cleaved to release three different proteases. Two of the proteases are active and can be inhibited by serine protease inhibitors, and one is thought to be catalytically inactive. This gene enhances the invasive capability of pancreatic cancer cells and may be involved in cancer progression. [provided by RefSeq, Jul 2016].
Transcript (Including UTRs)
   Position: hg19 chr19:2,389,784-2,414,056 Size: 24,273 Total Exon Count: 10 Strand: +
Coding Region
   Position: hg19 chr19:2,389,784-2,414,039 Size: 24,256 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:2,389,784-2,414,056)mRNA (may differ from genome)Protein (531 aa)
Gene SorterGenome BrowserOther Species FASTATable SchemaAlphaFoldBioGPS
EnsemblEntrez GeneExonPrimerGeneCardsGeneNetworkHGNC
LynxMGIOMIMPubMedTreefamUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: E7EMP4_HUMAN
DESCRIPTION: SubName: Full=Serase-3;
SIMILARITY: Belongs to the peptidase S1 family.
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): TMPRSS9
CDC HuGE Published Literature: TMPRSS9

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.08 RPKM in Testis
Total median expression: 16.61 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR 0.00170.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002172 - LDrepeatLR_classA_rpt
IPR009003 - Pept_cys/ser_Trypsin-like
IPR018114 - Peptidase_S1/S6_AS
IPR001254 - Peptidase_S1_S6
IPR001314 - Peptidase_S1A
IPR000082 - SEA

Pfam Domains:
PF00057 - Low-density lipoprotein receptor domain class A
PF00089 - Trypsin
PF01390 - SEA domain
PF09342 - Domain of unknown function (DUF1986)

SCOP Domains:
50494 - Trypsin-like serine proteases
82671 - SEA domain
57424 - LDL receptor-like module

ModBase Predicted Comparative 3D Structure on E7EMP4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
 Protein SequenceProtein Sequence   
 AlignmentAlignment   

-  Descriptions from all associated GenBank mRNAs
  AB109390 - Homo sapiens mRNA for Serase-1B, complete cds.
AB527446 - Synthetic construct DNA, clone: pF1KB7312, Homo sapiens TMPRSS9 gene for transmembrane protease, serine 9, without stop codon, in Flexi system.
BC140386 - Synthetic construct Homo sapiens clone IMAGE:100014449, MGC:173153 transmembrane protease, serine 9 (TMPRSS9) mRNA, encodes complete protein.
AJ488947 - Homo sapiens mRNA for polyserase-IB protein.
AJ488946 - Homo sapiens mRNA for polyserase-IA protein.
AK131261 - Homo sapiens cDNA FLJ16193 fis, clone BRTHA2018011, weakly similar to EPITHIN (EC 3.4.21.-).

-  Other Names for This Gene
  Alternate Gene Symbols: AB109390, E7EMP4, E7EMP4_HUMAN, NM_182973, NP_892018
UCSC ID: uc002lvv.1
RefSeq Accession: NM_182973
Protein: E7EMP4

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AB109390.1
exon count: 10CDS single in 3' UTR: no RNA size: 1628
ORF size: 1596CDS single in intron: no Alignment % ID: 99.94
txCdsPredict score: 2494.00frame shift in genome: no % Coverage: 99.08
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 40# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.