ID:TLE2_HUMAN DESCRIPTION: RecName: Full=Transducin-like enhancer protein 2; AltName: Full=Enhancer of split groucho-like protein 2; Short=ESG2; FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). SUBUNIT: Homooligomer and heterooligomer with other family members. Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5. INTERACTION: Q16531:DDB1; NbExp=2; IntAct=EBI-1176061, EBI-350322; SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: In all tissues examined, mostly in heart, brain, and muscle. PTM: Ubiquitinated by XIAP/BIRC4. SIMILARITY: Belongs to the WD repeat Groucho/TLE family. SIMILARITY: Contains 6 WD repeats.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q04725
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.