Human Gene ZNF560 (uc002mlp.1)
  Description: Homo sapiens zinc finger protein 560 (ZNF560), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:9,577,031-9,609,279 Size: 32,249 Total Exon Count: 10 Strand: -
Coding Region
   Position: hg19 chr19:9,577,250-9,585,989 Size: 8,740 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:9,577,031-9,609,279)mRNA (may differ from genome)Protein (790 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedReactomeTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN560_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 560;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 15 C2H2-type zinc fingers.
SIMILARITY: Contains 2 KRAB domains.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.79 RPKM in Testis
Total median expression: 7.64 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -59.20210-0.282 Picture PostScript Text
3' UTR -42.10219-0.192 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001909 - Krueppel-associated_box
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF01352 - KRAB box
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger
PF13913 - zinc-finger of a C2HC-type

SCOP Domains:
48695 - Multiheme cytochromes
109640 - KRAB domain (Kruppel-associated box, Pfam 01352)
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q96MR9
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005622 intracellular
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK056548 - Homo sapiens cDNA FLJ31986 fis, clone NT2RP7008720, weakly similar to ZINC FINGER PROTEIN 84.
JD428643 - Sequence 409667 from Patent EP1572962.
BC101039 - Homo sapiens cDNA clone IMAGE:40007877, containing frame-shift errors.
BC101040 - Homo sapiens zinc finger protein 560, mRNA (cDNA clone MGC:119491 IMAGE:40007878), complete cds.
BC101041 - Homo sapiens zinc finger protein 560, mRNA (cDNA clone MGC:119492 IMAGE:40007880), complete cds.
BC101042 - Homo sapiens zinc finger protein 560, mRNA (cDNA clone MGC:119493 IMAGE:40007881), complete cds.
JD244885 - Sequence 225909 from Patent EP1572962.
EU446578 - Synthetic construct Homo sapiens clone IMAGE:100070011; IMAGE:100011787; FLH257186.01L zinc finger protein 560 (ZNF560) gene, encodes complete protein.
LF375643 - JP 2014500723-A/183146: Polycomb-Associated Non-Coding RNAs.
JD328064 - Sequence 309088 from Patent EP1572962.
JD163115 - Sequence 144139 from Patent EP1572962.
JD402140 - Sequence 383164 from Patent EP1572962.
JD537571 - Sequence 518595 from Patent EP1572962.
JD422972 - Sequence 403996 from Patent EP1572962.
JD073580 - Sequence 54604 from Patent EP1572962.
MA611220 - JP 2018138019-A/183146: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q96MR9 (Reactome details) participates in the following event(s):

R-HSA-975040 KRAB-ZNF / KAP Interaction
R-HSA-212436 Generic Transcription Pathway
R-HSA-73857 RNA Polymerase II Transcription
R-HSA-74160 Gene expression (Transcription)

-  Other Names for This Gene
  Alternate Gene Symbols: NM_152476, NP_689689, Q495S9, Q495T1, Q96MR9, ZN560_HUMAN
UCSC ID: uc002mlp.1
RefSeq Accession: NM_152476
Protein: Q96MR9 (aka ZN560_HUMAN)
CCDS: CCDS12214.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_152476.2
exon count: 10CDS single in 3' UTR: no RNA size: 2802
ORF size: 2373CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 4931.50frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.