Human Gene PDE4A (uc002mom.2)
Description: Homo sapiens phosphodiesterase 4A, cAMP-specific (PDE4A), transcript variant 4, mRNA.RefSeq Summary (NM_006202): The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].Transcript (Including UTRs) Position: hg19 chr19:10,563,633-10,580,307 Size: 16,675 Total Exon Count: 10 Strand: +Coding Region Position: hg19 chr19:10,563,940-10,578,297 Size: 14,358 Coding Exon Count: 10
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): PDE4A
CDC HuGE Published Literature: PDE4A
Positive Disease Associations: Coronary Disease
Related Studies: Coronary Disease 0 ]
MalaCards Disease Associations
MalaCards Gene Search: PDE4A
Diseases sorted by gene-association score: asthma (9), respiratory failure (4), chronic lymphocytic leukemia (4), lung disease (3), pulmonary hypertension (2), bronchial disease (2), vasculogenic impotence (1), respiratory system disease (1), sexual disorder (1), acrodysostosis (1), corneal dystrophy, reis-bucklers type (1)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF00233 - 3'5'-cyclic nucleotide phosphodiesteraseSCOP Domains: 109604 - HD-domain/PDEase-likeModBase Predicted Comparative 3D Structure on P27815-4 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
DQ892448 - Synthetic construct clone IMAGE:100005078; FLH186425.01X; RZPDo839E0571D phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A) gene, encodes complete protein.DQ895660 - Synthetic construct Homo sapiens clone IMAGE:100010120; FLH186421.01L; RZPDo839E0561D phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila) (PDE4A) gene, encodes complete protein.AY593872 - Homo sapiens cAMP-specific phosphodiesterase (PDE4A) mRNA, complete cds.L20965 - Human phosphodiesterase mRNA, complete cds.JA482071 - Sequence 54 from Patent WO2011072091.JE980363 - Sequence 54 from Patent EP2862929.AY618547 - Homo sapiens cyclic AMP phosphodiesterase PDE4A11 (PDE4A) mRNA, partial cds, alternatively spliced.JA482072 - Sequence 55 from Patent WO2011072091.JE980364 - Sequence 55 from Patent EP2862929.AF073745 - Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A10 (PDE4A) mRNA, complete cds.JA482073 - Sequence 56 from Patent WO2011072091.JE980365 - Sequence 56 from Patent EP2862929.M37744 - Human cyclic AMP (cAMP)-specific phosphodiesterase mRNA, complete cds.U18087 - Human 3',5'-cyclic AMP phosphodiesterase HPDE4A6 mRNA, complete cds.S75213 - type-IVA cyclic AMP specific phosphodiesterase HPDE4A [human, T-cells, mRNA Partial, 2319 nt].BC038234 - Homo sapiens phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila), mRNA (cDNA clone MGC:46146 IMAGE:5732341), complete cds.JA482074 - Sequence 57 from Patent WO2011072091.JE980366 - Sequence 57 from Patent EP2862929.JD401472 - Sequence 382496 from Patent EP1572962.JD409887 - Sequence 390911 from Patent EP1572962.BC019864 - Homo sapiens phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila), mRNA (cDNA clone MGC:30168 IMAGE:4942336), complete cds.JD336593 - Sequence 317617 from Patent EP1572962.JD503650 - Sequence 484674 from Patent EP1572962.JD390086 - Sequence 371110 from Patent EP1572962.U97584 - Homo sapiens cyclic AMP-specific phosphodiesterase HSPDE4A1A (PDE4A) mRNA, complete cds.U68532 - Homo sapiens cyclic AMP specific phosphodiesterase RD1 (PDE4a) mRNA, complete cds.U18088 - Human 3',5'-cyclic AMP phosphodiesterase inactive splice variant HSPDE4A7A mRNA, complete cds.AY266362 - Homo sapiens phosphodiesterase isozyme 4 (PDE4) mRNA, partial cds.JD137049 - Sequence 118073 from Patent EP1572962.JD390456 - Sequence 371480 from Patent EP1572962.JD516599 - Sequence 497623 from Patent EP1572962.JD253294 - Sequence 234318 from Patent EP1572962.JD389276 - Sequence 370300 from Patent EP1572962.JD150456 - Sequence 131480 from Patent EP1572962.JD419404 - Sequence 400428 from Patent EP1572962.JD254490 - Sequence 235514 from Patent EP1572962.JD216470 - Sequence 197494 from Patent EP1572962.JD159559 - Sequence 140583 from Patent EP1572962.JD304003 - Sequence 285027 from Patent EP1572962.JD241664 - Sequence 222688 from Patent EP1572962.JD485883 - Sequence 466907 from Patent EP1572962.JD507190 - Sequence 488214 from Patent EP1572962.JD329547 - Sequence 310571 from Patent EP1572962.JD325599 - Sequence 306623 from Patent EP1572962.JD381828 - Sequence 362852 from Patent EP1572962.JD465655 - Sequence 446679 from Patent EP1572962.JD116590 - Sequence 97614 from Patent EP1572962.JD057672 - Sequence 38696 from Patent EP1572962.JD142147 - Sequence 123171 from Patent EP1572962.JD189177 - Sequence 170201 from Patent EP1572962.JD276368 - Sequence 257392 from Patent EP1572962.JD182559 - Sequence 163583 from Patent EP1572962.JD111632 - Sequence 92656 from Patent EP1572962.JD520752 - Sequence 501776 from Patent EP1572962.JD459539 - Sequence 440563 from Patent EP1572962.JD070719 - Sequence 51743 from Patent EP1572962.JD142018 - Sequence 123042 from Patent EP1572962.JD450076 - Sequence 431100 from Patent EP1572962.JD407162 - Sequence 388186 from Patent EP1572962.JD427382 - Sequence 408406 from Patent EP1572962.JD477971 - Sequence 458995 from Patent EP1572962.JD301055 - Sequence 282079 from Patent EP1572962.JD469005 - Sequence 450029 from Patent EP1572962.JD080065 - Sequence 61089 from Patent EP1572962.JD389642 - Sequence 370666 from Patent EP1572962.JD391316 - Sequence 372340 from Patent EP1572962.JD157893 - Sequence 138917 from Patent EP1572962.JD253121 - Sequence 234145 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
NM_006202.2
exon count:
10 CDS single in 3' UTR:
no
RNA size:
4276 ORF size:
1944 CDS single in intron:
no
Alignment % ID:
100.00 txCdsPredict score:
3850.00 frame shift in genome:
no
% Coverage:
99.65 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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