ID:JUNB_HUMAN DESCRIPTION: RecName: Full=Transcription factor jun-B; FUNCTION: Transcription factor involved in regulating gene activity following the primary growth factor response. Binds to the DNA sequence 5'-TGA[CG]TCA-3'. SUBUNIT: Binds DNA as a homodimer or as a heterodimer with another member of the Jun/Fos family. Interacts with ITCH (via its WW domains). INTERACTION: Q8N1L9:BATF2; NbExp=3; IntAct=EBI-748062, EBI-742695; Q86XI8:C19orf68; NbExp=2; IntAct=EBI-748062, EBI-2682158; SUBCELLULAR LOCATION: Nucleus. INDUCTION: By growth factors. PTM: Ubiquitinated by ITCH, leading to its degradation. SIMILARITY: Belongs to the bZIP family. Jun subfamily. SIMILARITY: Contains 1 bZIP (basic-leucine zipper) domain. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/JUNBID178.html"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/junb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47454 - A DNA-binding domain in eukaryotic transcription factors
ModBase Predicted Comparative 3D Structure on P17275
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0005515 protein binding GO:0008134 transcription factor binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001570 vasculogenesis GO:0001649 osteoblast differentiation GO:0001701 in utero embryonic development GO:0001829 trophectodermal cell differentiation GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0009314 response to radiation GO:0009612 response to mechanical stimulus GO:0009987 cellular process GO:0010941 regulation of cell death GO:0019221 cytokine-mediated signaling pathway GO:0030316 osteoclast differentiation GO:0032496 response to lipopolysaccharide GO:0032870 cellular response to hormone stimulus GO:0033687 osteoblast proliferation GO:0034097 response to cytokine GO:0042127 regulation of cell proliferation GO:0042493 response to drug GO:0045597 positive regulation of cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046697 decidualization GO:0051591 response to cAMP GO:0051726 regulation of cell cycle GO:0060136 embryonic process involved in female pregnancy GO:0060716 labyrinthine layer blood vessel development GO:0071277 cellular response to calcium ion