Description: Homo sapiens methylthioribose-1-phosphate isomerase 1 (MRI1), transcript variant 1, mRNA. RefSeq Summary (NM_001031727): This enzyme functions in the methionine salvage pathway by catalyzing the interconversion of methylthioribose-1-phosphate and methythioribulose-1-phosphate. Elevated expression of the encoded protein is associated with metastatic melanoma and this protein promotes melanoma cell invasion independent of its enzymatic activity. Mutations in this gene may be associated with vanishing white matter disease (VMWD). [provided by RefSeq, Jul 2016]. Transcript (Including UTRs) Position: hg19 chr19:13,875,337-13,885,096 Size: 9,760 Total Exon Count: 6 Strand: + Coding Region Position: hg19 chr19:13,875,403-13,883,095 Size: 7,693 Coding Exon Count: 6
ID:MTNA_HUMAN DESCRIPTION: RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi; Short=MTR-1-P isomerase; EC=5.3.1.23; AltName: Full=Mediator of RhoA-dependent invasion; AltName: Full=S-methyl-5-thioribose-1-phosphate isomerase; AltName: Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein; FUNCTION: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P). Independently from catalytic activity, promotes cell invasion in response to constitutive RhoA activation by promoting FAK tyrosine phosphorylation and stress fiber turnover. CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate. PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6. INTERACTION: Self; NbExp=3; IntAct=EBI-747381, EBI-747381; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cell projection. Note=Primarily nuclear, but cytoplasmic in cancer cells, with enrichment at leading edge of the plasma membrane in late stage tumor cells. INDUCTION: By RhoA activation in cancer cells (at protein level). SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BV20
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0008652 cellular amino acid biosynthetic process GO:0009086 methionine biosynthetic process GO:0019509 L-methionine biosynthetic process from methylthioadenosine GO:0044237 cellular metabolic process GO:0044249 cellular biosynthetic process