Human Gene CYP4F3 (uc002nbk.3)
  Description: Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 3 (CYP4F3), transcript variant 3, mRNA.
RefSeq Summary (NM_001199209): This gene, CYP4F3, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum. The enzyme starts the process of inactivating and degrading leukotriene B4, a potent mediator of inflammation. This gene is part of a cluster of cytochrome P450 genes on chromosome 19. Another member of this family, CYP4F8, is approximately 18 kb away. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2019].
Transcript (Including UTRs)
   Position: hg19 chr19:15,752,196-15,771,570 Size: 19,375 Total Exon Count: 12 Strand: +
Coding Region
   Position: hg19 chr19:15,752,226-15,770,195 Size: 17,970 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersGenetic AssociationsMalaCards
CTDGene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein Structure
Other SpeciesmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:15,752,196-15,771,570)mRNA (may differ from genome)Protein (520 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCLynxMalacardsMGIOMIMPubMed
TreefamUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: B7Z8Z3_HUMAN
DESCRIPTION: SubName: Full=CYP4F3 protein; SubName: Full=Cytochrome P450, family 4, subfamily F, polypeptide 3, isoform CRA_b; SubName: Full=cDNA FLJ52393, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30); SubName: Full=cDNA, FLJ79035, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30);
SIMILARITY: Belongs to the cytochrome P450 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): CYP4F3
CDC HuGE Published Literature: CYP4F3

-  MalaCards Disease Associations
  MalaCards Gene Search: CYP4F3
Diseases sorted by gene-association score: inflammatory bowel disease 6 (12), ascariasis (7), colonic benign neoplasm (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 76.09 RPKM in Liver
Total median expression: 139.12 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.3030-0.110 Picture PostScript Text
3' UTR -368.631375-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001128 - Cyt_P450
IPR017972 - Cyt_P450_CS
IPR002401 - Cyt_P450_E_grp-I

Pfam Domains:
PF00067 - Cytochrome P450

SCOP Domains:
48264 - Cytochrome P450

ModBase Predicted Comparative 3D Structure on B7Z8Z3
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  AK316136 - Homo sapiens cDNA, FLJ79035 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30).
AK296802 - Homo sapiens cDNA FLJ50565 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30).
AK298675 - Homo sapiens cDNA FLJ56125 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30).
AK296761 - Homo sapiens cDNA FLJ56100 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30).
LF384394 - JP 2014500723-A/191897: Polycomb-Associated Non-Coding RNAs.
AB002454 - Homo sapiens mRNA for leukotriene B4 omega-hydroxylase, complete cds.
AK304200 - Homo sapiens cDNA FLJ52393 complete cds, highly similar to Cytochrome P450 4F2 (EC 1.14.13.30).
BC136299 - Homo sapiens cytochrome P450, family 4, subfamily F, polypeptide 3, mRNA (cDNA clone MGC:167909 IMAGE:9020286), complete cds.
D12620 - Homo sapiens mRNA for cytochrome P-450LTBV, complete cds.
D12621 - Homo sapiens mRNA for cytochrome P-450LTBV, partial cds, clone:S-8.
AF054821 - Homo sapiens cytochrome P-450 mRNA, complete cds.
JD341276 - Sequence 322300 from Patent EP1572962.
AK303477 - Homo sapiens cDNA FLJ50432 complete cds, highly similar to Cytochrome P450 4F3 (EC 1.14.13.30).
JD439877 - Sequence 420901 from Patent EP1572962.
JD091802 - Sequence 72826 from Patent EP1572962.
JD558185 - Sequence 539209 from Patent EP1572962.
JD441031 - Sequence 422055 from Patent EP1572962.
JD412063 - Sequence 393087 from Patent EP1572962.
JD306073 - Sequence 287097 from Patent EP1572962.
JD276595 - Sequence 257619 from Patent EP1572962.
JD283083 - Sequence 264107 from Patent EP1572962.
JD096710 - Sequence 77734 from Patent EP1572962.
JD037844 - Sequence 18868 from Patent EP1572962.
JD042833 - Sequence 23857 from Patent EP1572962.
JD298872 - Sequence 279896 from Patent EP1572962.
JD563973 - Sequence 544997 from Patent EP1572962.
JD350398 - Sequence 331422 from Patent EP1572962.
JD324726 - Sequence 305750 from Patent EP1572962.
JD359328 - Sequence 340352 from Patent EP1572962.
JD146148 - Sequence 127172 from Patent EP1572962.
JD381372 - Sequence 362396 from Patent EP1572962.
JD063611 - Sequence 44635 from Patent EP1572962.
MA619971 - JP 2018138019-A/191897: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa00590 - Arachidonic acid metabolism
hsa01100 - Metabolic pathways

-  Other Names for This Gene
  Alternate Gene Symbols: AF054821, B7Z8Z3, B7Z8Z3_HUMAN, hCG_36819, NM_001199209, NP_001186138
UCSC ID: uc002nbk.3
RefSeq Accession: NM_001199209
Protein: B7Z8Z3 CCDS: CCDS59362.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AF054821.1
exon count: 12CDS single in 3' UTR: no RNA size: 1980
ORF size: 1563CDS single in intron: no Alignment % ID: 99.65
txCdsPredict score: 3326.00frame shift in genome: no % Coverage: 99.85
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 29# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.