Human Gene CEACAM5 (uc002orj.1)
Description: Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5), mRNA.
RefSeq Summary (NM_004363): This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015].
Transcript (Including UTRs)
Position: hg19 chr19:42,212,530-42,231,272 Size: 18,743 Total Exon Count: 9 Strand: +
Coding Region
Position: hg19 chr19:42,212,651-42,231,236 Size: 18,586 Coding Exon Count: 9
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: H9KVA7_HUMAN
DESCRIPTION: SubName: Full=Carcinoembryonic antigen-related cell adhesion molecule 5; Flags: Fragment;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: CEACAM5
Diseases sorted by gene-association score: rectal neoplasm (11), colorectal cancer (10), lung cancer (9), gallbladder cancer (9), papillary adenocarcinoma (9), urachal cancer (8), pancreatic cancer (7), gastrointestinal carcinoma (6), urachal adenocarcinoma (6), cystadenocarcinoma (5), colon adenocarcinoma (5), gastric adenocarcinoma (5), ureter adenocarcinoma (5), immature teratoma of ovary (5), vaccinia (5), adamantinoid basal cell epithelioma (4), adamantinoma of long bones (4), stomach cancer (4), small cell cancer of the lung, somatic (4), mucoepidermoid carcinoma (4), medullary thyroid carcinoma, familial (3), hepatocellular carcinoma (3), colorectal adenocarcinoma (3), anal paget's disease (3), gallbladder lymphoma (3), lung cancer susceptibility 3 (3), prostate signet ring cell adenocarcinoma (3), cholangitis (3), mucoepidermoid esophageal carcinoma (3), anus adenocarcinoma (3), esophageal cancer (3), mesothelioma, somatic (3), cholangiocarcinoma, susceptibility to (2), apocrine adenoma (2), cutaneous mucoepidermoid carcinoma (2), sigmoid neoplasm (2), granulomatous endometritis (2), mucinous cystadenofibroma (2), female urethral cancer (2), gallbladder squamous cell carcinoma (2), breast cancer (2), bile duct cystadenocarcinoma (2), liver leiomyoma (2), warthin tumor (2), rectum adenocarcinoma (2), cell type cancer (2), gastrointestinal system cancer (2), cutaneous adenocystic carcinoma (2), liver lymphoma (2), ovarian cystadenocarcinoma (2), breast mucoepidermoid carcinoma (2), eccrine acrospiroma (2), tracheal cancer (2), vulval paget's disease (2), pancreatic serous cystadenoma (2), intracystic papillary adenoma (2), gastric cancer, somatic (2), vulva adenocarcinoma (2), fox-fordyce disease (2), epididymis cancer (2), epididymis adenocarcinoma (2), intracranial chondrosarcoma (2), ovary adenocarcinoma (2), ovary serous adenocarcinoma (2), nodular hidradenoma (2), anal gland adenocarcinoma (2), bile duct adenocarcinoma (2), cervix endometriosis (2), splenic tuberculosis (2), adenosquamous gallbladder carcinoma (2), descending colon cancer (2), ovarian cancer, somatic (2), microinvasive gastric cancer (2), thymus adenocarcinoma (2), adenoid basal cell carcinoma (2), ovary epithelial cancer (2), malignant ovarian surface epithelial-stromal neoplasm (2), gastrointestinal system benign neoplasm (2), endocrine gland cancer (2), cardiomyopathy, familial hypertrophic, 9 (2), mucinous adenofibroma (2), secretory meningioma (2), pericardial tuberculosis (1), melanotic medulloblastoma (1), rete testis adenocarcinoma (1), aggressive digital papillary adenocarcinoma (1), malignant spiradenoma (1), chondroid chordoma (1), intestinal benign neoplasm (1), clear cell adenoma (1), gastric small cell carcinoma (1), thyroid cancer, nonmedullary, 2 (1), cell type benign neoplasm (1), mucocele of salivary gland (1), lymphohistiocytoid mesothelioma (1), eccrine adenocarcinoma (1), organ system benign neoplasm (1), atypical follicular adenoma (1), pancreas adenocarcinoma (1), liver sarcoma (1), bile duct mucoepidermoid carcinoma (1), transverse colon cancer (1), integumentary system cancer (1), pancreatic mucinous cystadenoma (1), hematocele of tunica vaginalis testis (1), breast adenomyoepithelioma (1), breast myoepithelial neoplasm (1), female reproductive organ cancer (1), rete testis neoplasm (1), tuberculous empyema (1), epidermolysis bullosa, junctional, herlitz type (1), clear cell acanthoma (1), juvenile type testicular granulosa cell tumor (1), gastric signet ring cell adenocarcinoma (1), prostate squamous cell carcinoma (1), xanthogranulomatous cholecystitis (1), testicular granulosa cell tumor (1), melanoacanthoma (1), malignant epithelial mesothelioma (1), mucinous ovarian cystadenoma (1), biliary papillomatosis (1), ovarian lymphoma (1), ovarian mucinous neoplasm (1), colonic benign neoplasm (1), orbital cyst (1), mixed ductal-endocrine carcinoma (1), tolosa-hunt syndrome (1), acute thyroiditis (1), breast mucinous carcinoma (1), breast squamous cell carcinoma (1), meibomian cyst (1), tuberculous peritonitis (1), femoral neuropathy (1), congenital epulis (1), malignant biphasic mesothelioma (1), miliaria (1), urethral benign neoplasm (1), cervical clear cell adenocarcinoma (1), spermatocele (1), chondroid lipoma (1), infiltrative basal cell carcinoma (1), extragonadal seminoma (1), superior mesenteric artery syndrome (1), holoprosencephaly 1 (1), testicular yolk sac tumor (1), pancreatic cystadenocarcinoma (1), cystitis cystica (1), cloacogenic carcinoma (1), breast metaplastic carcinoma (1)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR013098 - Ig_I-set
IPR003599 - Ig_sub
IPR003598 - Ig_sub2
IPR013106 - Ig_V-set
Pfam Domains: PF00047 - Immunoglobulin domain
PF07679 - Immunoglobulin I-set domain
PF07686 - Immunoglobulin V-set domain
PF13895 - Immunoglobulin domain
PF13927 - Immunoglobulin domain
SCOP Domains: 48726 - Immunoglobulin
ModBase Predicted Comparative 3D Structure on H9KVA7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Descriptions from all associated GenBank mRNAs
JD147700 - Sequence 128724 from Patent EP1572962.M29540 - Human carcinoembryonic antigen mRNA (CEA), complete cds.JD515355 - Sequence 496379 from Patent EP1572962.AK310844 - Homo sapiens cDNA, FLJ17886.BC034671 - Homo sapiens carcinoembryonic antigen-related cell adhesion molecule 5, mRNA (cDNA clone MGC:34212 IMAGE:5184800), complete cds.AK223101 - Homo sapiens mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 variant, clone: KAT04486.JD071438 - Sequence 52462 from Patent EP1572962.JD153999 - Sequence 135023 from Patent EP1572962.JD164612 - Sequence 145636 from Patent EP1572962.CR749337 - Homo sapiens mRNA; cDNA DKFZp781M2392 (from clone DKFZp781M2392).JD340028 - Sequence 321052 from Patent EP1572962.DQ896753 - Synthetic construct Homo sapiens clone IMAGE:100011213; FLH166370.01L; RZPDo839G0185D carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene, encodes complete protein.DQ890840 - Synthetic construct clone IMAGE:100003470; FLH166374.01X; RZPDo839G0186D carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) gene, encodes complete protein.CU689928 - Synthetic construct Homo sapiens gateway clone IMAGE:100020345 5' read CEACAM5 mRNA.KJ905171 - Synthetic construct Homo sapiens clone ccsbBroadEn_14581 CEACAM5 gene, encodes complete protein.AB852566 - Homo sapiens CEACAM5 mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 isoform 5D, complete cds.AB852567 - Homo sapiens CEACAM5 mRNA for carcinoembryonic antigen-related cell adhesion molecule 5 isoform 3D, complete cds.X16455 - Human mRNA for carcinoembryonic antigen pCEA80-11.M15042 - Human carcinoembryonic antigen mRNA.E01630 - cDNA encoding human carcinoembryonic antigen.LF366910 - JP 2014500723-A/174413: Polycomb-Associated Non-Coding RNAs.M17191 - Human carcinoembronyic antigen mRNA, partial cds.M16234 - Human carcinoembryonic antigen mRNA, 3' end.JD273129 - Sequence 254153 from Patent EP1572962.MA602487 - JP 2018138019-A/174413: Polycomb-Associated Non-Coding RNAs.
Other Names for This Gene
Alternate Gene Symbols: H9KVA7, H9KVA7_HUMAN, NM_004363, NP_004354, X16455UCSC ID: uc002orj.1RefSeq Accession: NM_004363
Protein: H9KVA7
CCDS: CCDS12584.1
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
X16455.1
exon count:
9 CDS single in 3' UTR:
no
RNA size:
2092
ORF size:
2106 CDS single in intron:
no
Alignment % ID:
99.95
txCdsPredict score:
4409.00 frame shift in genome:
no
% Coverage:
100.00
has start codon:
yes
stop codon in genome:
no
# of Alignments:
1
has end codon:
yes
retained intron:
no
# AT/AC introns
0
selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.