ID:DMRTD_HUMAN DESCRIPTION: RecName: Full=Doublesex- and mab-3-related transcription factor C2; FUNCTION: May be involved in sexual development. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Expressed in testis and pancreas. SIMILARITY: Belongs to the DMRT family. SIMILARITY: Contains 1 DM DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00751 - DM DNA binding domain PF15791 - Doublesex-and mab-3-related transcription factor C1 and C2
SCOP Domains: 82927 - Cysteine-rich DNA binding domain, (DM domain)
ModBase Predicted Comparative 3D Structure on Q8IXT2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003674 molecular_function GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0042803 protein homodimerization activity GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0007141 male meiosis I GO:0007290 spermatid nucleus elongation GO:0007548 sex differentiation GO:0008150 biological_process GO:0030154 cell differentiation GO:1900111 positive regulation of histone H3-K9 dimethylation GO:1900114 positive regulation of histone H3-K9 trimethylation