Human Gene DMRTC2 (uc002ors.3)
  Description: Homo sapiens DMRT-like family C2 (DMRTC2), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:42,349,086-42,356,397 Size: 7,312 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg19 chr19:42,351,497-42,355,764 Size: 4,268 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:42,349,086-42,356,397)mRNA (may differ from genome)Protein (367 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtOMIMPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: DMRTD_HUMAN
DESCRIPTION: RecName: Full=Doublesex- and mab-3-related transcription factor C2;
FUNCTION: May be involved in sexual development.
SUBCELLULAR LOCATION: Nucleus (Potential).
TISSUE SPECIFICITY: Expressed in testis and pancreas.
SIMILARITY: Belongs to the DMRT family.
SIMILARITY: Contains 1 DM DNA-binding domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.91 RPKM in Testis
Total median expression: 30.06 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.7083-0.322 Picture PostScript Text
3' UTR -169.42633-0.268 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001275 - DM_DNA-bd
IPR026607 - DMRT/dsx/mab-3

Pfam Domains:
PF00751 - DM DNA binding domain
PF15791 - Doublesex-and mab-3-related transcription factor C1 and C2

SCOP Domains:
82927 - Cysteine-rich DNA binding domain, (DM domain)

ModBase Predicted Comparative 3D Structure on Q8IXT2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003674 molecular_function
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007141 male meiosis I
GO:0007290 spermatid nucleus elongation
GO:0007548 sex differentiation
GO:0008150 biological_process
GO:0030154 cell differentiation
GO:1900111 positive regulation of histone H3-K9 dimethylation
GO:1900114 positive regulation of histone H3-K9 trimethylation

Cellular Component:
GO:0001741 XY body
GO:0005575 cellular_component
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  KJ899425 - Synthetic construct Homo sapiens clone ccsbBroadEn_08819 DMRTC2 gene, encodes complete protein.
AK057404 - Homo sapiens cDNA FLJ32842 fis, clone TESTI2003327, weakly similar to Testis-specific protein.
AK301822 - Homo sapiens cDNA FLJ61444 complete cds, highly similar to Doublesex- and mab-3-related transcription factor C2.
BC039266 - Homo sapiens DMRT-like family C2, mRNA (cDNA clone MGC:33892 IMAGE:5298983), complete cds.
BC029202 - Homo sapiens DMRT-like family C2, mRNA (cDNA clone MGC:35186 IMAGE:5170924), complete cds.
AB463571 - Synthetic construct DNA, clone: pF1KB7620, Homo sapiens DMRTC2 gene for DMRT-like family C2, without stop codon, in Flexi system.
EU446672 - Synthetic construct Homo sapiens clone IMAGE:100070029; IMAGE:100011881; FLH258311.01L DMRT-like family C2 (DMRTC2) gene, encodes complete protein.
CU691704 - Synthetic construct Homo sapiens gateway clone IMAGE:100019102 5' read DMRTC2 mRNA.
AJ291669 - Homo sapiens partial mRNA for Doublesex-mab-3 (DM) domain, (DMRTC2 gene).
JD111911 - Sequence 92935 from Patent EP1572962.
JD341211 - Sequence 322235 from Patent EP1572962.
JD097804 - Sequence 78828 from Patent EP1572962.
JD182004 - Sequence 163028 from Patent EP1572962.
JD380199 - Sequence 361223 from Patent EP1572962.
JD194167 - Sequence 175191 from Patent EP1572962.
JD272751 - Sequence 253775 from Patent EP1572962.
JD207822 - Sequence 188846 from Patent EP1572962.
JD454483 - Sequence 435507 from Patent EP1572962.
JD357002 - Sequence 338026 from Patent EP1572962.
JD536509 - Sequence 517533 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: DMRTD_HUMAN, NM_001040283, NP_001035373, Q8IXT2, Q8N6Q2, Q96M39, Q96SD4
UCSC ID: uc002ors.3
RefSeq Accession: NM_001040283
Protein: Q8IXT2 (aka DMRTD_HUMAN)
CCDS: CCDS33034.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_001040283.1
exon count: 9CDS single in 3' UTR: no RNA size: 1821
ORF size: 1104CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2403.00frame shift in genome: no % Coverage: 99.95
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.