Human Gene PHLDB3 (uc002own.4)
  Description: Homo sapiens pleckstrin homology-like domain, family B, member 3 (PHLDB3), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:43,979,255-44,008,985 Size: 29,731 Total Exon Count: 16 Strand: -
Coding Region
   Position: hg19 chr19:43,979,562-44,008,270 Size: 28,709 Coding Exon Count: 15 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:43,979,255-44,008,985)mRNA (may differ from genome)Protein (640 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsGeneNetwork
H-INVHGNCHPRDLynxMGIneXtProt
PubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PHLB3_HUMAN
DESCRIPTION: RecName: Full=Pleckstrin homology-like domain family B member 3;
DOMAIN: The PH domain mediates the binding to phosphoinositides (By similarity).
SIMILARITY: Contains 1 PH domain.
SEQUENCE CAUTION: Sequence=BAC05082.1; Type=Erroneous termination; Positions=169; Note=Translated as Glu;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 16.63 RPKM in Testis
Total median expression: 173.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -124.50259-0.481 Picture PostScript Text
3' UTR -143.64307-0.468 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011993 - PH_like_dom
IPR001849 - Pleckstrin_homology

Pfam Domains:
PF00169 - PH domain

SCOP Domains:
50729 - PH domain-like

ModBase Predicted Comparative 3D Structure on Q6NSJ2
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0019899 enzyme binding


-  Descriptions from all associated GenBank mRNAs
  BC157852 - Homo sapiens pleckstrin homology-like domain, family B, member 3, mRNA (cDNA clone IMAGE:9057071), complete cds.
BC171853 - Homo sapiens pleckstrin homology-like domain, family B, member 3, mRNA (cDNA clone IMAGE:9054507), complete cds.
BC007947 - Homo sapiens pleckstrin homology-like domain, family B, member 3, mRNA (cDNA clone IMAGE:4299555), partial cds.
JD445055 - Sequence 426079 from Patent EP1572962.
JD484460 - Sequence 465484 from Patent EP1572962.
JD157420 - Sequence 138444 from Patent EP1572962.
JD390273 - Sequence 371297 from Patent EP1572962.
JD394928 - Sequence 375952 from Patent EP1572962.
BC070094 - Homo sapiens pleckstrin homology-like domain, family B, member 3, mRNA (cDNA clone MGC:87511 IMAGE:4374205), complete cds.
AK097512 - Homo sapiens cDNA FLJ40193 fis, clone TESTI2019430.
KJ905124 - Synthetic construct Homo sapiens clone ccsbBroadEn_14518 PHLDB3-like gene, encodes complete protein.
BC029299 - Homo sapiens pleckstrin homology-like domain, family B, member 3, mRNA (cDNA clone IMAGE:5171114).

-  Other Names for This Gene
  Alternate Gene Symbols: NM_198850, NP_942147, PHLB3_HUMAN, Q6NSJ2, Q8N7Z4
UCSC ID: uc002own.4
RefSeq Accession: NM_198850
Protein: Q6NSJ2 (aka PHLB3_HUMAN)
CCDS: CCDS12621.2

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_198850.3
exon count: 16CDS single in 3' UTR: no RNA size: 2505
ORF size: 1923CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 2123.00frame shift in genome: no % Coverage: 99.36
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.