Description: Homo sapiens MAP/microtubule affinity-regulating kinase 4 (MARK4), transcript variant 1, mRNA. RefSeq Summary (NM_001199867): This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]. Transcript (Including UTRs) Position: hg19 chr19:45,754,516-45,783,992 Size: 29,477 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr19:45,774,749-45,783,740 Size: 8,992 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AB049127 - Homo sapiens MARKL1 mRNA for MAP/microtubule affinity-regulating kinase like 1, complete cds. AB088047 - Homo sapiens MARKL1L mRNA for microtubule affinity-regulating kinase-like1, complete cds. JD476273 - Sequence 457297 from Patent EP1572962. JD129819 - Sequence 110843 from Patent EP1572962. BC071948 - Homo sapiens MAP/microtubule affinity-regulating kinase 4, mRNA (cDNA clone IMAGE:6579540), complete cds. JD116760 - Sequence 97784 from Patent EP1572962. JD399333 - Sequence 380357 from Patent EP1572962. AK075272 - Homo sapiens cDNA FLJ90791 fis, clone THYRO1001593, moderately similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78 (EC 2.7.1.-). JD476111 - Sequence 457135 from Patent EP1572962. AY057448 - Homo sapiens MARK4 serine/threonine protein kinase mRNA, complete cds. AB058763 - Homo sapiens KIAA1860 mRNA for KIAA1860 protein. KJ903010 - Synthetic construct Homo sapiens clone ccsbBroadEn_12404 MARK4 gene, encodes complete protein. AB384310 - Synthetic construct DNA, clone: pF1KSDA1860, Homo sapiens MARK4 gene for MAP/microtubule affinity-regulating kinase 4, complete cds, without stop codon, in Flexi system. BC166620 - Synthetic construct Homo sapiens clone IMAGE:100066346, MGC:195483 MAP/microtubule affinity-regulating kinase 4 (MARK4) mRNA, encodes complete protein. AY120867 - Homo sapiens MAP/microtubule affinity-regulating kinase-like 1 (MARK4) mRNA, MARK4-L allele, complete cds; alternatively spliced. AK074578 - Homo sapiens cDNA FLJ90097 fis, clone HEMBA1005929, weakly similar to H.sapiens mRNA for serine/threonine protein kinase EMK. AK027619 - Homo sapiens cDNA FLJ14713 fis, clone NT2RP3000845, moderately similar to PUTATIVE SERINE/THREONINE-PROTEIN KINASE P78 (EC 2.7.1.-). GQ901019 - Homo sapiens clone HEL-T-131 epididymis secretory sperm binding protein mRNA, complete cds. AB073663 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00650, full insert sequence.
US Server
