The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF08208 - DNA-directed RNA polymerase I subunit RPA34.5
ModBase Predicted Comparative 3D Structure on O15446-2
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
U86751 - Human nucleolar fibrillar center protein (ASE-1) mRNA, complete cds. BC054044 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone IMAGE:6166782), partial cds. BC046141 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone IMAGE:5581697), partial cds. BC108889 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone MGC:118851 IMAGE:40001010), complete cds. AK292183 - Homo sapiens cDNA FLJ75784 complete cds, highly similar to Homo sapiens CD3E antigen, epsilon polypeptide associated protein (CD3EAP), mRNA. BC009705 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone IMAGE:3901859), partial cds. BC028109 - Homo sapiens cDNA clone IMAGE:5249001, containing frame-shift errors. BC065251 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone IMAGE:6140210). JD283132 - Sequence 264156 from Patent EP1572962. JD231453 - Sequence 212477 from Patent EP1572962. AF017633 - Homo sapiens CD3e-associated protein (CAST) mRNA, complete cds. BC038992 - Homo sapiens CD3e molecule, epsilon associated protein, mRNA (cDNA clone MGC:47680 IMAGE:6052122), complete cds. EU446938 - Synthetic construct Homo sapiens clone IMAGE:100069957; IMAGE:100012147; FLH257135.01L CD3e molecule, epsilon associated protein (CD3EAP) gene, encodes complete protein. JD370411 - Sequence 351435 from Patent EP1572962. JD530525 - Sequence 511549 from Patent EP1572962. JD437727 - Sequence 418751 from Patent EP1572962. JD316317 - Sequence 297341 from Patent EP1572962. JD466302 - Sequence 447326 from Patent EP1572962. JD064539 - Sequence 45563 from Patent EP1572962. JD264680 - Sequence 245704 from Patent EP1572962. JD134466 - Sequence 115490 from Patent EP1572962. JD131718 - Sequence 112742 from Patent EP1572962. JD514069 - Sequence 495093 from Patent EP1572962. JD460170 - Sequence 441194 from Patent EP1572962. JD242428 - Sequence 223452 from Patent EP1572962. JD051628 - Sequence 32652 from Patent EP1572962. JD321976 - Sequence 303000 from Patent EP1572962. JD220947 - Sequence 201971 from Patent EP1572962. JD489452 - Sequence 470476 from Patent EP1572962. JD070251 - Sequence 51275 from Patent EP1572962. JD303873 - Sequence 284897 from Patent EP1572962. JD101306 - Sequence 82330 from Patent EP1572962. JD251845 - Sequence 232869 from Patent EP1572962. JD311614 - Sequence 292638 from Patent EP1572962. JD538713 - Sequence 519737 from Patent EP1572962. JD040258 - Sequence 21282 from Patent EP1572962. JD374378 - Sequence 355402 from Patent EP1572962. JD113029 - Sequence 94053 from Patent EP1572962. JD323454 - Sequence 304478 from Patent EP1572962. JD347798 - Sequence 328822 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O15446 (Reactome details) participates in the following event(s):
R-HSA-73865 Assembly of RNA Polymerase I Holoenzyme (human) R-HSA-73757 Binding of RRN3 to RNA Polymerase I R-HSA-5250947 B-WICH complex binds rDNA promoter R-HSA-73758 Recruitment of Active RNA Polymerase I to SL1:phos.UBF-1:rDNA Promoter R-HSA-74994 Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box R-HSA-73769 Loss of Rrn3 from RNA Polymerase I promoter escape complex R-HSA-74992 Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box R-HSA-5250930 B-WICH recruits histone acetyltransferases R-HSA-74993 PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box R-HSA-74986 Elongation of pre-rRNA transcript R-HSA-427366 Transcription of intergenic spacer of the rRNA gene R-HSA-5250938 B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9 R-HSA-73762 RNA Polymerase I Transcription Initiation R-HSA-5250924 B-WICH complex positively regulates rRNA expression R-HSA-73854 RNA Polymerase I Promoter Clearance R-HSA-73863 RNA Polymerase I Transcription Termination R-HSA-73772 RNA Polymerase I Promoter Escape R-HSA-5250913 Positive epigenetic regulation of rRNA expression R-HSA-73864 RNA Polymerase I Transcription R-HSA-73777 RNA Polymerase I Chain Elongation R-HSA-427413 NoRC negatively regulates rRNA expression R-HSA-212165 Epigenetic regulation of gene expression R-HSA-74160 Gene expression (Transcription) R-HSA-5250941 Negative epigenetic regulation of rRNA expression