Description: Homo sapiens chorionic gonadotropin, beta polypeptide 8 (CGB7), mRNA. RefSeq Summary (NM_033183): This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:49,550,895-49,559,852 Size: 8,958 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr19:49,550,912-49,558,632 Size: 7,721 Coding Exon Count: 3
ID:CGHB_HUMAN DESCRIPTION: RecName: Full=Choriogonadotropin subunit beta; Short=CG-beta; AltName: Full=Chorionic gonadotrophin chain beta; Flags: Precursor; FUNCTION: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Placenta. DEVELOPMENTAL STAGE: Made by the first trimester placenta. PHARMACEUTICAL: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie- restricted diets. SIMILARITY: Belongs to the glycoprotein hormones subunit beta family. SEQUENCE CAUTION: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation; WEB RESOURCE: Name=Wikipedia; Note=Chorionic gonadotropin entry; URL="http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P01233
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.