Human Gene SLC17A7 (uc002pno.3)
  Description: Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 (SLC17A7), mRNA.
RefSeq Summary (NM_020309): The protein encoded by this gene is a vesicle-bound, sodium-dependent phosphate transporter that is specifically expressed in the neuron-rich regions of the brain. It is preferentially associated with the membranes of synaptic vesicles and functions in glutamate transport. The protein shares 82% identity with the differentiation-associated Na-dependent inorganic phosphate cotransporter and they appear to form a distinct class within the Na+/Pi cotransporter family. [provided by RefSeq, Jul 2008]. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Transcript (Including UTRs)
   Position: hg19 chr19:49,932,655-49,937,946 Size: 5,292 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr19:49,933,776-49,936,181 Size: 2,406 Coding Exon Count: 4 

Page IndexSequence and LinksPrimersGenetic AssociationsMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:49,932,655-49,937,946)mRNA (may differ from genome)Protein (222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblExonPrimerGeneCardsGeneNetwork
H-INVHGNCLynxMalacardsMGIPubMed
TreefamUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Genetic Association Studies of Complex Diseases and Disorders
  Genetic Association Database (archive): SLC17A7
CDC HuGE Published Literature: SLC17A7

-  MalaCards Disease Associations
  MalaCards Gene Search: SLC17A7
Diseases sorted by gene-association score: spinocerebellar ataxia 27 (3), deafness, autosomal dominant 25 (2), schizophrenia (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 284.06 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 1615.72 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -166.70437-0.381 Picture PostScript Text
3' UTR -312.461121-0.279 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011701 - MFS
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt

SCOP Domains:
103473 - MFS general substrate transporter

ModBase Predicted Comparative 3D Structure on A8K0Q7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
 Protein Sequence    
 Alignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0055085 transmembrane transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  LF207662 - JP 2014500723-A/15165: Polycomb-Associated Non-Coding RNAs.
BC059379 - Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, mRNA (cDNA clone MGC:71639 IMAGE:5262415), complete cds.
AK057879 - Homo sapiens cDNA FLJ25150 fis, clone CBR07695, highly similar to Homo sapiens BNPI mRNA for brain-specific Na-dependent inorganic phosphate cotransporter.
AK294226 - Homo sapiens cDNA FLJ60479 complete cds, highly similar to Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, mRNA.
AB032436 - Homo sapiens BNPI mRNA for brain-specific Na-dependent inorganic phosphate cotransporter, complete cds.
AK294405 - Homo sapiens cDNA FLJ59680 complete cds, highly similar to Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7, mRNA.
AK289622 - Homo sapiens cDNA FLJ75352 complete cds.
LF212104 - JP 2014500723-A/19607: Polycomb-Associated Non-Coding RNAs.
AK095659 - Homo sapiens cDNA FLJ38340 fis, clone FCBBF3027903, highly similar to Homo sapiens solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter).
MA443239 - JP 2018138019-A/15165: Polycomb-Associated Non-Coding RNAs.
MA447681 - JP 2018138019-A/19607: Polycomb-Associated Non-Coding RNAs.
AK091061 - Homo sapiens cDNA FLJ33742 fis, clone BRAWH2019053, highly similar to Homo sapiens BNPI mRNA for brain-specific Na-dependent inorganic phosphate cotransporter.
AX746758 - Sequence 283 from Patent EP1308459.
LF367789 - JP 2014500723-A/175292: Polycomb-Associated Non-Coding RNAs.
JD396774 - Sequence 377798 from Patent EP1572962.
JD040756 - Sequence 21780 from Patent EP1572962.
JD371486 - Sequence 352510 from Patent EP1572962.
JD084263 - Sequence 65287 from Patent EP1572962.
JD166549 - Sequence 147573 from Patent EP1572962.
JD418295 - Sequence 399319 from Patent EP1572962.
JD555030 - Sequence 536054 from Patent EP1572962.
JD491565 - Sequence 472589 from Patent EP1572962.
JD423658 - Sequence 404682 from Patent EP1572962.
JD400066 - Sequence 381090 from Patent EP1572962.
JD073588 - Sequence 54612 from Patent EP1572962.
JD518356 - Sequence 499380 from Patent EP1572962.
JD554195 - Sequence 535219 from Patent EP1572962.
LF367787 - JP 2014500723-A/175290: Polycomb-Associated Non-Coding RNAs.
MA603366 - JP 2018138019-A/175292: Polycomb-Associated Non-Coding RNAs.
MA603364 - JP 2018138019-A/175290: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0Q7, A8K0Q7_HUMAN, AX746758
UCSC ID: uc002pno.3
RefSeq Accession: NM_020309
Protein: A8K0Q7

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AX746758.1
exon count: 7CDS single in 3' UTR: no RNA size: 2140
ORF size: 669CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 1082.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.