Description: Homo sapiens adaptor-related protein complex 2, alpha 1 subunit (AP2A1), transcript variant 1, mRNA. RefSeq Summary (NM_014203): This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:50,304,804-50,307,797 Size: 2,994 Total Exon Count: 2 Strand: + Coding Region Position: hg19 chr19:50,305,082-50,305,838 Size: 757 Coding Exon Count: 2
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Descriptions from all associated GenBank mRNAs
AK302005 - Homo sapiens cDNA FLJ61453 complete cds, highly similar to Adapter-relatedprotein complex 2 alpha- 1 subunit. BC014214 - Homo sapiens adaptor-related protein complex 2, alpha 1 subunit, mRNA (cDNA clone MGC:20679 IMAGE:4111165), complete cds. AL136925 - Homo sapiens mRNA; cDNA DKFZp586H1320 (from clone DKFZp586H1320). DQ892253 - Synthetic construct clone IMAGE:100004883; FLH184557.01X; RZPDo839H03144D adaptor-related protein complex 2, alpha 1 subunit (AP2A1) gene, encodes complete protein. DQ895454 - Synthetic construct Homo sapiens clone IMAGE:100009914; FLH184553.01L; RZPDo839H03143D adaptor-related protein complex 2, alpha 1 subunit (AP2A1) gene, encodes complete protein. AB527855 - Synthetic construct DNA, clone: pF1KB8539, Homo sapiens AP2A1 gene for adaptor-related protein complex 2, alpha 1 subunit, without stop codon, in Flexi system. KJ905137 - Synthetic construct Homo sapiens clone ccsbBroadEn_14534 AP2A1-like gene, encodes complete protein. KX018644 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 5 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018645 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 6 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018646 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 7 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018647 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 8 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018648 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 9 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018649 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 10 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018650 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 11 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018651 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 12 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018652 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 13 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018653 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 14 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018654 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 15 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018655 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 16 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018656 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 17 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018657 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 18 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018658 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 19 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018659 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 20 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018660 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 21 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018661 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 22 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018662 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 23 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018663 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 24 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018664 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 25 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018665 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 26 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018666 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 27 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018667 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 28 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018668 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 29 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018669 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 30 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018670 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 31 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018671 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 32 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018672 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 33 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018673 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 34 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018674 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 35 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018675 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 36 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018676 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 37 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018677 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 38 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018678 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 39 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018679 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 40 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018680 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 41 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018681 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 42 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018682 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 43 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018683 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 44 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018684 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 45 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018685 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 46 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018686 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 47 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018687 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 48 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018688 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 49 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018689 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 50 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018690 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 51 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018691 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 52 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018692 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 53 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018693 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 54 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018694 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 55 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018695 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 56 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018696 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 57 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018697 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 58 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018698 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 59 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018699 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 60 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018700 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 61 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018701 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 62 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018702 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 63 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018703 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 64 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018704 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 65 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018705 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 66 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018706 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 67 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018707 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 68 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018708 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 69 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018709 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 70 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018710 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 71 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018711 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 72 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018712 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 73 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018713 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 74 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018714 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 75 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018715 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 76 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018716 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 77 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018717 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 78 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018718 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 79 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018719 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 80 (AP2A1) mRNA, partial sequence; alternatively spliced. KX018720 - Homo sapiens nonfunctional adaptor-related protein complex 2 alpha 1 subunit transcript variant 81 (AP2A1) mRNA, partial sequence; alternatively spliced. AK094317 - Homo sapiens cDNA FLJ36998 fis, clone BRACE2007295, highly similar to ALPHA-ADAPTIN A. AK090661 - Homo sapiens cDNA FLJ33342 fis, clone BRACE2002834, moderately similar to ALPHA-ADAPTIN A. JD425571 - Sequence 406595 from Patent EP1572962. JD112121 - Sequence 93145 from Patent EP1572962. JD488598 - Sequence 469622 from Patent EP1572962. JD205363 - Sequence 186387 from Patent EP1572962. JD176501 - Sequence 157525 from Patent EP1572962. JD066708 - Sequence 47732 from Patent EP1572962. JD088863 - Sequence 69887 from Patent EP1572962. JD268450 - Sequence 249474 from Patent EP1572962. JD510974 - Sequence 491998 from Patent EP1572962. JD184005 - Sequence 165029 from Patent EP1572962. JD155893 - Sequence 136917 from Patent EP1572962. JD366540 - Sequence 347564 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04144 - Endocytosis hsa05016 - Huntington's disease
BioCarta from NCI Cancer Genome Anatomy Project h_bArrestinPathway - ¿-arrestins in GPCR Desensitization h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin h_ptdinsPathway - Phosphoinositides and their downstream targets.