Human Gene LILRB3 (uc002qeh.1)
Description: Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (LILRB3), transcript variant 2, mRNA.RefSeq Summary (NM_006864): This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Transcript (Including UTRs) Position: hg19 chr19:54,720,147-54,746,724 Size: 26,578 Total Exon Count: 13 Strand: -Coding Region Position: hg19 chr19:54,720,962-54,746,600 Size: 25,639 Coding Exon Count: 13
Data last updated at UCSC: 2013-06-14
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: B5MCX0_HUMAN DESCRIPTION: SubName: Full=Leukocyte immunoglobulin-like receptor subfamily B member 3;CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.
Primer design for this transcript
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LILRB3
CDC HuGE Published Literature: LILRB3
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007110 - Ig-likeIPR013783 - Ig-like_foldIPR003599 - Ig_subPfam Domains: PF13895 - Immunoglobulin domainSCOP Domains: 48726 - ImmunoglobulinModBase Predicted Comparative 3D Structure on B5MCX0 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse Rat Zebrafish D. melanogaster C. elegans S. cerevisiae
No ortholog No ortholog No ortholog No ortholog No ortholog No ortholog Gene Details Gene Sorter
Descriptions from all associated GenBank mRNAs
AF041262 - Homo sapiens immunoglobulin-like transcript 8 mRNA, complete cds.BC028153 - Homo sapiens cDNA clone IMAGE:5217134.JD518130 - Sequence 499154 from Patent EP1572962.JD185459 - Sequence 166483 from Patent EP1572962.JD444127 - Sequence 425151 from Patent EP1572962.JD445092 - Sequence 426116 from Patent EP1572962.AK290917 - Homo sapiens cDNA FLJ75015 complete cds, highly similar to Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 (LILRB3), mRNA.U91928 - Human clone HL9 monocyte inhibitory receptor precursor mRNA, complete cds.AF025533 - Homo sapiens leucocyte immunoglobulin-like receptor-3 (LIR-3) mRNA, complete cds.AK223265 - Homo sapiens mRNA for leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 variant, clone: SYN01171.AF000575 - Homo sapiens clone 16 immunoglobulin-like transcript 5 mRNA, complete cds.AF009632 - Homo sapiens clone 17.10 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009633 - Homo sapiens clone 17.11 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009634 - Homo sapiens clone 17.6 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009635 - Homo sapiens clone 17.7 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009636 - Homo sapiens clone 17.8 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009637 - Homo sapiens clone 19 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009638 - Homo sapiens clone 22 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009639 - Homo sapiens clone 31 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009640 - Homo sapiens clone 33 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009641 - Homo sapiens clone 36 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009642 - Homo sapiens clone 40 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009643 - Homo sapiens clone 6 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF009644 - Homo sapiens clone 41 immunoglobulin-like transcript 5 protein mRNA, complete cds.AF031553 - Homo sapiens clone DC.1 immunoglobulin-like transcript 5 mRNA, complete cds.AF031554 - Homo sapiens clone 17.18 immunoglobulin-like transcript 5 mRNA, complete cds.AF031555 - Homo sapiens clone 17.23 immunoglobulin-like transcript 5 mRNA, complete cds.AF031556 - Homo sapiens clone 17.30 immunoglobulin-like transcript 5 mRNA, complete cds.JD316755 - Sequence 297779 from Patent EP1572962.JD437697 - Sequence 418721 from Patent EP1572962.BC104993 - Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3, mRNA (cDNA clone MGC:132653 IMAGE:8143996), complete cds.BC112198 - Homo sapiens leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3, mRNA (cDNA clone MGC:138403 IMAGE:8327666), complete cds.KJ902188 - Synthetic construct Homo sapiens clone ccsbBroadEn_11582 LILRB3 gene, encodes complete protein.EU814627 - Homo sapiens immunoglobulin-like transcript 5 antigenic variant 1 mRNA, complete cds.EU814628 - Homo sapiens immunoglobulin-like transcript 5 antigenic variant 2 mRNA, complete cds.KC918856 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*06 allele, partial cds.KC918859 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*09 allele, partial cds.KC918851 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*01 allele, partial cds.KC918852 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*02 allele, partial cds.KC918853 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*03 allele, partial cds.KC918854 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*04 allele, partial cds.KC918855 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*05 allele, partial cds.KC918857 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*07 allele, partial cds.KC918858 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*08 allele, partial cds.KC918860 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*10 allele, partial cds.KC918861 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*11 allele, partial cds.KC918862 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*12 allele, partial cds.KC918863 - Homo sapiens LILRB3 (LILRB3) mRNA, LILRB3*13 allele, partial cds.EU915603 - Homo sapiens leukocyte immunoglobulin-like receptor subfamily B member 3 soluble isoform 1 (LILRB3) mRNA, complete cds, alternatively spliced.EU915604 - Homo sapiens leukocyte immunoglobulin-like receptor subfamily B member 3 soluble isoform 2 (LILRB3) mRNA, complete cds, alternatively spliced.EU915605 - Homo sapiens leukocyte immunoglobulin-like receptor subfamily B member 3 soluble isoform 3 (LILRB3) mRNA, complete cds, alternatively spliced.KF294243 - Homo sapiens isolate 14-10-5_30Q LILRB3 (LILRB3) mRNA, partial cds.KF294244 - Homo sapiens isolate 20-5-8_30Q LILRB3 (LILRB3) mRNA, partial cds.AF344427 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-016 allele, partial cds.AF344435 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-024 allele, partial cds.KF294233 - Homo sapiens isolate 28-11-6_98(TAC) LILRB3 (LILRB3) mRNA, partial cds.KF294237 - Homo sapiens isolate 13-5-8_36R LILRB3 (LILRB3) mRNA, partial cds.KF294234 - Homo sapiens isolate 15-7-10_36Q LILRB3 (LILRB3) mRNA, partial cds.AF344429 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-018 allele, partial cds.AF344434 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-023 allele, partial cds.AF344437 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-026 allele, partial cds.AF344438 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-027 allele, partial cds.BC041708 - Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6, mRNA (cDNA clone IMAGE:5751768).KC918864 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*01 allele, complete cds.KC918865 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*02 allele, complete cds.KC918866 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*03 allele, complete cds.KC918867 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*04 allele, complete cds.KC918868 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*05 allele, complete cds.KC918869 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*06 allele, complete cds.KC918870 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*07 allele, complete cds.KC918871 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*08 allele, complete cds.KC918872 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*09 allele, complete cds.KC918873 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*10 allele, complete cds.KC918874 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*11 allele, complete cds.KC918875 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*12 allele, complete cds.KC918876 - Homo sapiens LILRA6 (LILRA6) mRNA, LILRA6*13 allele, complete cds.BC141549 - Synthetic construct Homo sapiens clone IMAGE:100014513, MGC:175298 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 (LILRA6) mRNA, encodes complete protein.BC156794 - Synthetic construct Homo sapiens clone IMAGE:100062556, MGC:190560 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 (LILRA6) mRNA, encodes complete protein.AB463830 - Synthetic construct DNA, clone: pF1KB7252, Homo sapiens LILRA6 gene for leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6, without stop codon, in Flexi system.KF294251 - Homo sapiens isolate 15-7-10_46W LILRA6 (LILRA6) mRNA, partial cds.KF294247 - Homo sapiens isolate 4-07_36Q LILRA6 (LILRA6) mRNA, partial cds.KF294245 - Homo sapiens isolate 28-11-6_36Q LILRA6 (LILRA6) mRNA, partial cds.KF294249 - Homo sapiens isolate 15-4-8_36Q LILRA6 (LILRA6) mRNA, partial cds.KF294252 - Homo sapiens isolate Dec12_36Q LILRA6 (LILRA6) mRNA, partial cds.KF294253 - Homo sapiens isolate 25-1-7 LILRA6 (LILRA6) mRNA, partial cds.KF294248 - Homo sapiens isolate 4-6-8 LILRA6 (LILRA6) mRNA, partial cds.KF294246 - Homo sapiens isolate 13-5-8_36Q LILRA6 (LILRA6) mRNA, partial cds.KF294238 - Homo sapiens isolate 4-6-8_36R LILRB3 (LILRB3) mRNA, partial cds.KF294235 - Homo sapiens isolate 4-07_36Q LILRB3 (LILRB3) mRNA, partial cds.KF294236 - Homo sapiens isolate 7-6-7(1)_36R LILRB3 (LILRB3) mRNA, partial cds.KF294239 - Homo sapiens isolate 18-4-8_36R LILRB3 (LILRB3) mRNA, partial cds.KF294240 - Homo sapiens isolate 15-7-10_36R LILRB3 (LILRB3) mRNA, partial cds.KF294241 - Homo sapiens isolate 15-4-8_36R LILRB3 (LILRB3) mRNA, partial cds.KF294242 - Homo sapiens isolate 20-4-7 LILRB3 (LILRB3) mRNA, partial cds.AF344428 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-017 allele, partial cds.AF344430 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-019 allele, partial cds.AF344431 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-020 allele, partial cds.AF344432 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-021 allele, partial cds.AF344433 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-022 allele, partial cds.AF344436 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-025 allele, partial cds.AF344439 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-028 allele, partial cds.AF344440 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-029 allele, partial cds.AF344441 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-030 allele, partial cds.AF344442 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-031 allele, partial cds.AF344443 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-032 allele, partial cds.AF344651 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-033 allele, partial cds.AF344652 - Homo sapiens immunoglobulin-like transcript 5 (LILRB3) mRNA, LILRB3-034 allele, partial cds.JD076865 - Sequence 57889 from Patent EP1572962.MA878034 - JP 2018536436-A/9870: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878033 - JP 2018536436-A/9869: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878032 - JP 2018536436-A/9868: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878031 - JP 2018536436-A/9867: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878030 - JP 2018536436-A/9866: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878006 - JP 2018536436-A/9842: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878001 - JP 2018536436-A/9837: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA878000 - JP 2018536436-A/9836: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877992 - JP 2018536436-A/9828: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877816 - JP 2018536436-A/9652: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877815 - JP 2018536436-A/9651: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877814 - JP 2018536436-A/9650: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877813 - JP 2018536436-A/9649: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877810 - JP 2018536436-A/9646: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877805 - JP 2018536436-A/9641: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877744 - JP 2018536436-A/9580: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877743 - JP 2018536436-A/9579: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877742 - JP 2018536436-A/9578: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877736 - JP 2018536436-A/9572: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877735 - JP 2018536436-A/9571: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877734 - JP 2018536436-A/9570: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877727 - JP 2018536436-A/9563: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877726 - JP 2018536436-A/9562: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.MA877574 - JP 2018536436-A/9410: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600446 - KR 1020180133840-A/10606: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600445 - KR 1020180133840-A/10605: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600444 - KR 1020180133840-A/10604: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600443 - KR 1020180133840-A/10603: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600442 - KR 1020180133840-A/10602: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600418 - KR 1020180133840-A/10578: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600413 - KR 1020180133840-A/10573: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600412 - KR 1020180133840-A/10572: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600404 - KR 1020180133840-A/10564: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600228 - KR 1020180133840-A/10388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600227 - KR 1020180133840-A/10387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600226 - KR 1020180133840-A/10386: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600225 - KR 1020180133840-A/10385: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600222 - KR 1020180133840-A/10382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600217 - KR 1020180133840-A/10377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600156 - KR 1020180133840-A/10316: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600155 - KR 1020180133840-A/10315: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600154 - KR 1020180133840-A/10314: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600148 - KR 1020180133840-A/10308: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600147 - KR 1020180133840-A/10307: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600146 - KR 1020180133840-A/10306: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600139 - KR 1020180133840-A/10299: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY600138 - KR 1020180133840-A/10298: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.LY599986 - KR 1020180133840-A/10146: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04662 - B cell receptor signaling pathway
Other Names for This Gene
Alternate Gene Symbols: AF031556, B5MCX0, B5MCX0_HUMAN, NM_006864, NP_006855UCSC ID: uc002qeh.1RefSeq Accession: NM_006864 Protein: B5MCX0
Gene Model Information
category:
coding
nonsense-mediated-decay:
no
RNA accession:
AF031556.1
exon count:
13 CDS single in 3' UTR:
no
RNA size:
2063 ORF size:
1896 CDS single in intron:
no
Alignment % ID:
99.13 txCdsPredict score:
3195.00 frame shift in genome:
no
% Coverage:
100.00 has start codon:
yes
stop codon in genome:
no
# of Alignments:
1 has end codon:
yes
retained intron:
no
# AT/AC introns
0 selenocysteine:
no
end bleed into intron:
0 # strange splices:
0
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
US Server
