Description: Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (LILRA3), transcript variant 1, mRNA. RefSeq Summary (NM_006865): This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]. Transcript (Including UTRs) Position: hg19 chr19:54,799,855-54,804,265 Size: 4,411 Total Exon Count: 7 Strand: - Coding Region Position: hg19 chr19:54,800,046-54,804,173 Size: 4,128 Coding Exon Count: 7
To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3
Genetic Association Studies of Complex Diseases and Disorders
Genetic Association Database (archive): LILRA3 CDC HuGE Published Literature: LILRA3 Positive Disease Associations: multiple sclerosis Related Studies:
multiple sclerosis Koch, S. et al. 2005, Association of multiple sclerosis with ILT6 deficiency., Genes and immunity. 2005 Aug;6(5):445-7.
[PubMed 15815690]
ILT6 deficiency is associated with MS in the German population and hence a likely risk factor for autoimmune disorders.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8N6C8
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
AF041262 - Homo sapiens immunoglobulin-like transcript 8 mRNA, complete cds. BC028208 - Homo sapiens leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3, mRNA (cDNA clone MGC:39966 IMAGE:5215423), complete cds. AF025527 - Homo sapiens leucocyte immunoglobulin-like receptor-4 (LIR-4) mRNA, complete cds. U91927 - Human clone HM31 monocyte inhibitory receptor precursor mRNA, partial cds. AF014923 - Homo sapiens immunoglobulin-like transcript 6 (ILT6) mRNA, complete cds. AF014924 - Homo sapiens immunoglobulin-like transcript 6a (ILT6a) mRNA, complete cds. U91926 - Human clone HM43 monocyte inhibitory receptor precursor mRNA, complete cds. JD357448 - Sequence 338472 from Patent EP1572962. JD077841 - Sequence 58865 from Patent EP1572962. JD451013 - Sequence 432037 from Patent EP1572962. JD451012 - Sequence 432036 from Patent EP1572962. KJ898335 - Synthetic construct Homo sapiens clone ccsbBroadEn_07729 LILRA3 gene, encodes complete protein. DQ891075 - Synthetic construct clone IMAGE:100003705; FLH169102.01X; RZPDo839G0694D leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (LILRA3) gene, encodes complete protein. DQ894258 - Synthetic construct Homo sapiens clone IMAGE:100008718; FLH169098.01L; RZPDo839G0693D leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 (LILRA3) gene, encodes complete protein. AB590305 - Synthetic construct DNA, clone: pFN21AE1373, Homo sapiens LILRA3 gene for leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3, without stop codon, in Flexi system. CU688428 - Synthetic construct Homo sapiens gateway clone IMAGE:100019402 5' read LILRA3 mRNA. JD316931 - Sequence 297955 from Patent EP1572962. JD148072 - Sequence 129096 from Patent EP1572962. JD463682 - Sequence 444706 from Patent EP1572962. JD227135 - Sequence 208159 from Patent EP1572962. MA877816 - JP 2018536436-A/9652: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877815 - JP 2018536436-A/9651: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877814 - JP 2018536436-A/9650: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877813 - JP 2018536436-A/9649: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877812 - JP 2018536436-A/9648: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877811 - JP 2018536436-A/9647: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877810 - JP 2018536436-A/9646: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877805 - JP 2018536436-A/9641: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877796 - JP 2018536436-A/9632: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877795 - JP 2018536436-A/9631: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877794 - JP 2018536436-A/9630: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877744 - JP 2018536436-A/9580: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877743 - JP 2018536436-A/9579: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877740 - JP 2018536436-A/9576: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877739 - JP 2018536436-A/9575: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877738 - JP 2018536436-A/9574: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877737 - JP 2018536436-A/9573: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877736 - JP 2018536436-A/9572: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877735 - JP 2018536436-A/9571: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877721 - JP 2018536436-A/9557: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877674 - JP 2018536436-A/9510: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877664 - JP 2018536436-A/9500: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877663 - JP 2018536436-A/9499: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877662 - JP 2018536436-A/9498: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877614 - JP 2018536436-A/9450: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877613 - JP 2018536436-A/9449: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877612 - JP 2018536436-A/9448: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877611 - JP 2018536436-A/9447: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877603 - JP 2018536436-A/9439: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877602 - JP 2018536436-A/9438: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877601 - JP 2018536436-A/9437: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877596 - JP 2018536436-A/9432: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877595 - JP 2018536436-A/9431: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877594 - JP 2018536436-A/9430: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877593 - JP 2018536436-A/9429: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877592 - JP 2018536436-A/9428: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877589 - JP 2018536436-A/9425: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877586 - JP 2018536436-A/9422: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877557 - JP 2018536436-A/9393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877556 - JP 2018536436-A/9392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877552 - JP 2018536436-A/9388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA877551 - JP 2018536436-A/9387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600228 - KR 1020180133840-A/10388: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600227 - KR 1020180133840-A/10387: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600226 - KR 1020180133840-A/10386: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600225 - KR 1020180133840-A/10385: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600224 - KR 1020180133840-A/10384: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600223 - KR 1020180133840-A/10383: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600222 - KR 1020180133840-A/10382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600217 - KR 1020180133840-A/10377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600208 - KR 1020180133840-A/10368: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600207 - KR 1020180133840-A/10367: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600206 - KR 1020180133840-A/10366: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600156 - KR 1020180133840-A/10316: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600155 - KR 1020180133840-A/10315: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600152 - KR 1020180133840-A/10312: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600151 - KR 1020180133840-A/10311: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600150 - KR 1020180133840-A/10310: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600149 - KR 1020180133840-A/10309: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600148 - KR 1020180133840-A/10308: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600147 - KR 1020180133840-A/10307: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600133 - KR 1020180133840-A/10293: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600086 - KR 1020180133840-A/10246: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600076 - KR 1020180133840-A/10236: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600075 - KR 1020180133840-A/10235: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600074 - KR 1020180133840-A/10234: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600026 - KR 1020180133840-A/10186: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600025 - KR 1020180133840-A/10185: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600024 - KR 1020180133840-A/10184: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600023 - KR 1020180133840-A/10183: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600015 - KR 1020180133840-A/10175: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600014 - KR 1020180133840-A/10174: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600013 - KR 1020180133840-A/10173: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600008 - KR 1020180133840-A/10168: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600007 - KR 1020180133840-A/10167: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600006 - KR 1020180133840-A/10166: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600005 - KR 1020180133840-A/10165: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600004 - KR 1020180133840-A/10164: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY600001 - KR 1020180133840-A/10161: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY599998 - KR 1020180133840-A/10158: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY599969 - KR 1020180133840-A/10129: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY599968 - KR 1020180133840-A/10128: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY599964 - KR 1020180133840-A/10124: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY599963 - KR 1020180133840-A/10123: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q8N6C8 (Reactome details) participates in the following event(s):
R-HSA-6799350 Exocytosis of specific granule membrane proteins R-HSA-6798747 Exocytosis of tertiary granule membrane proteins R-HSA-6800426 Exocytosis of ficolin-rich granule membrane proteins R-HSA-199043 LILRs interact with MHC Class I R-HSA-6798695 Neutrophil degranulation R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-HSA-168249 Innate Immune System R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System