Human Gene ZNF837 (uc002qsl.4)
  Description: Homo sapiens zinc finger protein 837 (ZNF837), transcript variant 2, mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:58,878,990-58,892,389 Size: 13,400 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:58,879,104-58,880,699 Size: 1,596 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:58,878,990-58,892,389)mRNA (may differ from genome)Protein (531 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
LynxMGIneXtProtPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN837_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 837;
FUNCTION: May be involved in transcriptional regulation (By similarity).
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 8 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.38 RPKM in Thyroid
Total median expression: 66.14 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -99.40221-0.450 Picture PostScript Text
3' UTR -31.10114-0.273 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF13894 - C2H2-type zinc finger

SCOP Domains:
48695 - Multiheme cytochromes
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q96EG3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AF049883 - Homo sapiens hypoxia-regulated factor-8 (HRF-8) mRNA, 3' untranslated region.
BC012365 - Homo sapiens zinc finger protein 837, mRNA (cDNA clone MGC:20521 IMAGE:4576341), complete cds.
KJ895315 - Synthetic construct Homo sapiens clone ccsbBroadEn_04709 ZNF837 gene, encodes complete protein.
BC029960 - Homo sapiens zinc finger protein 837, mRNA (cDNA clone IMAGE:5178641).
JD118592 - Sequence 99616 from Patent EP1572962.
JD325733 - Sequence 306757 from Patent EP1572962.
JD040848 - Sequence 21872 from Patent EP1572962.
JD211348 - Sequence 192372 from Patent EP1572962.
JD205892 - Sequence 186916 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: NM_138466, NP_612475, Q96EG3, ZN837_HUMAN
UCSC ID: uc002qsl.4
RefSeq Accession: NM_138466
Protein: Q96EG3 (aka ZN837_HUMAN)
CCDS: CCDS46216.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: NM_138466.1
exon count: 3CDS single in 3' UTR: no RNA size: 1948
ORF size: 1596CDS single in intron: no Alignment % ID: 100.00
txCdsPredict score: 3310.00frame shift in genome: no % Coverage: 99.13
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.