Human Gene ZBTB45 (uc002qtf.3)
  Description: Homo sapiens zinc finger and BTB domain containing 45 (ZBTB45), mRNA.
Transcript (Including UTRs)
   Position: hg19 chr19:59,024,897-59,031,188 Size: 6,292 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr19:59,025,421-59,029,040 Size: 3,620 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2013-06-14

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:59,024,897-59,031,188)mRNA (may differ from genome)Protein (511 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
GeneNetworkH-INVHGNCHPRDLynxMGI
neXtProtPubMedTreefamUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZBT45_HUMAN
DESCRIPTION: RecName: Full=Zinc finger and BTB domain-containing protein 45; AltName: Full=Zinc finger protein 499;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Potential).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 1 BTB (POZ) domain.
SIMILARITY: Contains 4 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.10 RPKM in Brain - Cortex
Total median expression: 232.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -24.9080-0.311 Picture PostScript Text
3' UTR -232.52524-0.444 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000210 - BTB/POZ-like
IPR011333 - BTB/POZ_fold
IPR013069 - BTB_POZ
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF00096 - Zinc finger, C2H2 type
PF00651 - BTB/POZ domain
PF13894 - C2H2-type zinc finger
PF13912 - C2H2-type zinc finger

SCOP Domains:
54695 - POZ domain
57667 - C2H2 and C2HC zinc fingers

ModBase Predicted Comparative 3D Structure on Q96K62
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007399 nervous system development

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AL831909 - Homo sapiens mRNA; cDNA DKFZp547H249 (from clone DKFZp547H249).
BC024738 - Homo sapiens zinc finger and BTB domain containing 45, mRNA (cDNA clone MGC:29999 IMAGE:5110354), complete cds.
AK130056 - Homo sapiens cDNA FLJ26546 fis, clone LNF00276.
AK027392 - Homo sapiens cDNA FLJ14486 fis, clone MAMMA1002650, weakly similar to Mus musculus ODA-8S protein mRNA.
JD141115 - Sequence 122139 from Patent EP1572962.
JD218473 - Sequence 199497 from Patent EP1572962.
JD557481 - Sequence 538505 from Patent EP1572962.
JD162776 - Sequence 143800 from Patent EP1572962.
JD259353 - Sequence 240377 from Patent EP1572962.
JD532526 - Sequence 513550 from Patent EP1572962.
JD328995 - Sequence 310019 from Patent EP1572962.
JD466566 - Sequence 447590 from Patent EP1572962.
KJ905579 - Synthetic construct Homo sapiens clone ccsbBroadEn_15200 ZBTB45 gene, encodes complete protein.
EU446546 - Synthetic construct Homo sapiens clone IMAGE:100070193; IMAGE:100011755; FLH257306.01L zinc finger and BTB domain containing 45 (ZBTB45) gene, encodes complete protein.
JD507792 - Sequence 488816 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AK027392, NM_032792, NP_116181, Q96K62, ZBT45_HUMAN, ZNF499
UCSC ID: uc002qtf.3
RefSeq Accession: NM_032792
Protein: Q96K62 (aka ZBT45_HUMAN)
CCDS: CCDS12984.1

-  Gene Model Information
 
category: coding nonsense-mediated-decay: no RNA accession: AK027392.1
exon count: 3CDS single in 3' UTR: no RNA size: 2138
ORF size: 1536CDS single in intron: no Alignment % ID: 99.95
txCdsPredict score: 3272.00frame shift in genome: no % Coverage: 100.00
has start codon: yes stop codon in genome: no # of Alignments: 1
has end codon: yes retained intron: no # AT/AC introns 0
selenocysteine: no end bleed into intron: 0# strange splices: 0
Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.