Description: Homo sapiens centromere protein A (CENPA), transcript variant 1, mRNA. RefSeq Summary (NM_001042426): Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]. Transcript (Including UTRs) Position: hg19 chr2:27,008,882-27,017,455 Size: 8,574 Total Exon Count: 4 Strand: + Coding Region Position: hg19 chr2:27,009,065-27,016,147 Size: 7,083 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P49450-2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC011013 - Homo sapiens centromere protein A, mRNA (cDNA clone IMAGE:4286607), **** WARNING: chimeric clone ****. U14518 - Human centromere protein-A (CENP-A) mRNA, complete cds. BC000881 - Homo sapiens centromere protein A, mRNA (cDNA clone MGC:5165 IMAGE:3461992), complete cds. JD148475 - Sequence 129499 from Patent EP1572962. JD382053 - Sequence 363077 from Patent EP1572962. BC002703 - Homo sapiens centromere protein A, mRNA (cDNA clone MGC:3892 IMAGE:3626578), complete cds. JD127768 - Sequence 108792 from Patent EP1572962. CU674442 - Synthetic construct Homo sapiens gateway clone IMAGE:100017911 5' read CENPA mRNA. HQ448742 - Synthetic construct Homo sapiens clone IMAGE:100072188; CCSB002737_02 centromere protein A (CENPA) gene, encodes complete protein. JF432571 - Synthetic construct Homo sapiens clone IMAGE:100073806 centromere protein A (CENPA) gene, encodes complete protein. KJ890897 - Synthetic construct Homo sapiens clone ccsbBroadEn_00291 CENPA gene, encodes complete protein. KJ890898 - Synthetic construct Homo sapiens clone ccsbBroadEn_00292 CENPA gene, encodes complete protein. BT007246 - Homo sapiens centromere protein A, 17kDa mRNA, complete cds. JD385354 - Sequence 366378 from Patent EP1572962. JD174291 - Sequence 155315 from Patent EP1572962. JD313921 - Sequence 294945 from Patent EP1572962. JD273204 - Sequence 254228 from Patent EP1572962. JD082333 - Sequence 63357 from Patent EP1572962. JD466412 - Sequence 447436 from Patent EP1572962. JD172975 - Sequence 153999 from Patent EP1572962. JD448985 - Sequence 430009 from Patent EP1572962. JD224953 - Sequence 205977 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P49450 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-606326 HJURP:CENPA complex localizes to the centromere R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-774815 Nucleosome assembly R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-73886 Chromosome Maintenance