Description: Homo sapiens urocortin (UCN), mRNA. RefSeq Summary (NM_003353): This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]. Transcript (Including UTRs) Position: hg19 chr2:27,530,265-27,531,130 Size: 866 Total Exon Count: 2 Strand: - Coding Region Position: hg19 chr2:27,530,389-27,530,763 Size: 375 Coding Exon Count: 1
ID:UCN1_HUMAN DESCRIPTION: RecName: Full=Urocortin; Flags: Precursor; FUNCTION: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. SUBUNIT: Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain). SUBCELLULAR LOCATION: Secreted. SIMILARITY: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P55089
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001934 positive regulation of protein phosphorylation GO:0001964 startle response GO:0006954 inflammatory response GO:0006979 response to oxidative stress GO:0007186 G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007565 female pregnancy GO:0007605 sensory perception of sound GO:0007611 learning or memory GO:0007631 feeding behavior GO:0008306 associative learning GO:0009060 aerobic respiration GO:0010469 regulation of receptor activity GO:0010628 positive regulation of gene expression GO:0010629 negative regulation of gene expression GO:0010996 response to auditory stimulus GO:0030157 pancreatic juice secretion GO:0030307 positive regulation of cell growth GO:0031064 negative regulation of histone deacetylation GO:0031175 neuron projection development GO:0032099 negative regulation of appetite GO:0032355 response to estradiol GO:0032755 positive regulation of interleukin-6 production GO:0032967 positive regulation of collagen biosynthetic process GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0034199 activation of protein kinase A activity GO:0035176 social behavior GO:0035483 gastric emptying GO:0042756 drinking behavior GO:0043066 negative regulation of apoptotic process GO:0043117 positive regulation of vascular permeability GO:0043950 positive regulation of cAMP-mediated signaling GO:0045727 positive regulation of translation GO:0045740 positive regulation of DNA replication GO:0045776 negative regulation of blood pressure GO:0045792 negative regulation of cell size GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0046888 negative regulation of hormone secretion GO:0048265 response to pain GO:0051384 response to glucocorticoid GO:0051461 positive regulation of corticotropin secretion GO:0051966 regulation of synaptic transmission, glutamatergic GO:0060452 positive regulation of cardiac muscle contraction GO:0060455 negative regulation of gastric acid secretion GO:0060547 negative regulation of necrotic cell death GO:0060548 negative regulation of cell death GO:0090280 positive regulation of calcium ion import GO:1901215 negative regulation of neuron death GO:2000252 negative regulation of feeding behavior GO:2000987 positive regulation of behavioral fear response
US Server
